AIM: To investigate the expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas. METHODS: The expressions of collagen type IV, MMP-2 and MMP-9 was in normal and colorectal cancer tissues of 30 patients whose clinical stages were Dukes'B and C was detected with immunohistochennical staining. And the relationship among collagen type IV, MMP-2 and MMP-9 was analysed. RESULTS: The expression of collagen type IV was significantly decreased in colorectal cancer tissues. The expression of MMP-2 and MMP-9 was not detected in normal colorectal tissues but it was significantly increased in colorectal cancer tissues. There was a negative correlation between the expression of collagen type IV and MMP-9. CONCLUSION: The expression of collagen type IV in colorectal cancer tissues is lower than that in normal tissues. MMP-9 may play an important role in the degradation of collagen type IV in colorectal cancer.
AIM: To investigate the expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas. METHODS: The expressions of collagen type IV, MMP-2 and MMP-9 was in normal and colorectal cancer tissues of 30 patients whose clinical stages were Dukes'B and C was detected with immunohistochennical staining. And the relationship among collagen type IV, MMP-2 and MMP-9 was analysed. RESULTS: The expression of collagen type IV was significantly decreased in colorectal cancer tissues. The expression of MMP-2 and MMP-9 was not detected in normal colorectal tissues but it was significantly increased in colorectal cancer tissues. There was a negative correlation between the expression of collagen type IV and MMP-9. CONCLUSION: The expression of collagen type IV in colorectal cancer tissues is lower than that in normal tissues. MMP-9 may play an important role in the degradation of collagen type IV in colorectal cancer.
Authors: Magdalena Groblewska; Barbara Mroczko; Mariusz Gryko; Anna Pryczynicz; Katarzyna Guzińska-Ustymowicz; Bogusław Kędra; Andrzej Kemona; Maciej Szmitkowski Journal: Tumour Biol Date: 2014-01-07
Authors: Dawid Stefaniuk; Tomasz Misztal; Mateusz Pięt; Adrian Zając; Magdalena Kopycińska; Anna Matuszewska; Marta Ruminowicz-Stefaniuk; Łukasz Matuszewski; Natalia Marcińczyk; Anna Belcarz; Jerzy Żuchowski; Ilona Skrabalak; Marcin Grąz; Beata Ciołek; Roman Paduch; Magdalena Jaszek Journal: Biomolecules Date: 2021-08-24