Literature DB >> 18781963

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: novel pharmacological agents in the treatment of ischemia reperfusion injury.

Costas Giaginis1, Gerasimos Tsourouflis, Stamatios Theocharis.   

Abstract

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands constitute important insulin sensitizers that have already been used for the treatment of human metabolic disorders, exerting also pleiotropic effects on inflammatory related diseases and cancer. Ischemia-reperfusion injury that is mainly associated with organ transplantation constitutes a serious complication with a great relevance in clinical practice. Accumulating experimental data have recently revealed that natural and synthetic PPAR-gamma ligands exert beneficial effects against ischemia-reperfusion injury. The present review summarizes the available information on the role of PPAR-gamma ligands in ischemia-reperfusion injury amongst the different organ systems. Taking into consideration the data so far, PPAR-gamma ligands seem to represent potential therapeutic agents in the aim to reduce or even prevent injury associated with ischemia-reperfusion.

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Year:  2008        PMID： 18781963     DOI： 10.2174/156652408785748022

Source DB:  PubMed          Journal:  Curr Mol Med        ISSN： 1566-5240            Impact factor:   2.222


  24 in total

1.  Prostaglandin A1 Inhibits the Cognitive Decline of APP/PS1 Transgenic Mice via PPARγ/ABCA1-dependent Cholesterol Efflux Mechanisms.

Authors:  Guo-Biao Xu; Liu-Qing Yang; Pei-Pei Guan; Zhan-You Wang; Pu Wang
Journal:  Neurotherapeutics       Date:  2019-04       Impact factor: 7.620

2.  Rosiglitazone-activated PPARγ induces neurotrophic factor-α1 transcription contributing to neuroprotection.

Authors:  Erwan Thouennon; Yong Cheng; Vida Falahatian; Niamh X Cawley; Yoke Peng Loh
Journal:  J Neurochem       Date:  2015-06-01       Impact factor: 5.372

3.  Expression of peroxisome proliferator activated receptor-gamma (PPAR-γ) in human non-small cell lung carcinoma: correlation with clinicopathological parameters, proliferation and apoptosis related molecules and patients' survival.

Authors:  Costantinos Giaginis; Ekaterini Politi; Paraskevi Alexandrou; John Sfiniadakis; Gregory Kouraklis; Stamatios Theocharis
Journal:  Pathol Oncol Res       Date:  2012-03-18       Impact factor: 3.201

4.  Peroxisome proliferator-activated receptor γ (PPARγ) mediates the protective effect of quercetin against myocardial ischemia-reperfusion injury via suppressing the NF-κB pathway.

Authors:  Xinyu Liu; Zhangjie Yu; Xian Huang; Yi Gao; Xiuzhi Wang; Jianmin Gu; Song Xue
Journal:  Am J Transl Res       Date:  2016-12-15       Impact factor: 4.060

Review 5.  Modulation of diabetic retinopathy pathophysiology by natural medicines through PPAR-γ-related pharmacology.

Authors:  Min K Song; Basil D Roufogalis; Tom H W Huang
Journal:  Br J Pharmacol       Date:  2012-01       Impact factor: 8.739

6.  15-Deoxy-∆12,14-PGJ 2, by activating peroxisome proliferator-activated receptor-gamma, suppresses p22phox transcription to protect brain endothelial cells against hypoxia-induced apoptosis.

Authors:  Jui-Sheng Wu; Hsin-Da Tsai; Chien-Yu Huang; Jin-Jer Chen; Teng-Nan Lin
Journal:  Mol Neurobiol       Date:  2013-12-19       Impact factor: 5.590

Review 7.  Peroxisome proliferator-activated receptor gamma (PPAR-γ) and neurodegenerative disorders.

Authors:  Yu-Chang Chen; Jui-Sheng Wu; Hsin-Da Tsai; Chien-Yu Huang; Jin-Jer Chen; Grace Y Sun; Teng-Nan Lin
Journal:  Mol Neurobiol       Date:  2012-03-21       Impact factor: 5.590

8.  Peroxisome proliferator-activated receptor-γ in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival.

Authors:  Stamatios Theocharis; Jerzy Klijanienko; Constantinos Giaginis; Jose Rodriguez; Thomas Jouffroy; Angelique Girod; Daniel Point; Gerasimos Tsourouflis; Xavier Satre-Garau
Journal:  J Cancer Res Clin Oncol       Date:  2011-02       Impact factor: 4.553

9.  PPAR-γ Ameliorates Neuronal Apoptosis and Ischemic Brain Injury via Suppressing NF-κB-Driven p22phox Transcription.

Authors:  Jui-Sheng Wu; Hsin-Da Tsai; Wai-Mui Cheung; Chung Y Hsu; Teng-Nan Lin
Journal:  Mol Neurobiol       Date:  2015-06-25       Impact factor: 5.590

Review 10.  PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty.

Authors:  Janice V Huang; Clifford R Greyson; Gregory G Schwartz
Journal:  J Lipid Res       Date:  2012-06-08       Impact factor: 5.922
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