Literature DB >> 18781910

Decreasing systemic toxicity via transdermal delivery of anticancer drugs.

Jia-You Fang1, Pei-Feng Liu, Chun-Ming Huang.   

Abstract

When used at a high dose, many anticancer drugs produce undesirable side effects including hepatotoxicity. Transdermal delivery bypasses first-pass metabolism, allowing the use of a lower dose of drug while decreasing systemic toxicity. In this review, we summarize various advanced technologies for improving anticancer drug delivery via the skin. This technology is discussed in the context of three anticancer drugs, 5-fluorouracil (5-FU), methotrexate (MTX) and 5-aminolevulinic acid (5-ALA). The use of a erbium:YAG (Er:YAG) laser for transdermal delivery of anticancer drugs is specifically highlighted in this review.

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Year:  2008        PMID： 18781910     DOI： 10.2174/138920008785821693

Source DB:  PubMed          Journal:  Curr Drug Metab        ISSN： 1389-2002            Impact factor:   3.731


  8 in total

1.  The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors.

Authors:  Mukaddes Izci; Christy Maksoudian; Bella B Manshian; Stefaan J Soenen
Journal:  Chem Rev       Date:  2021-01-14       Impact factor: 60.622

2.  Delivery of Methotrexate and Characterization of Skin Treated by Fabricated PLGA Microneedles and Fractional Ablative Laser.

Authors:  Hiep X Nguyen; Ajay K Banga
Journal:  Pharm Res       Date:  2018-02-21       Impact factor: 4.200

3.  Activation of cAMP Signaling in Response to α-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells.

Authors:  Wesuk Kang; Soyoon Park; Dabin Choi; Bomin Son; Taesun Park
Journal:  Int J Mol Sci       Date:  2022-08-11       Impact factor: 6.208

4.  Synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and its inhibition of liver cancer characteristics in vitro and in vivo.

Authors:  Mingrong Cheng; Xiaoyan Gao; Yong Wang; Houxiang Chen; Bing He; Hongzhi Xu; Yingchun Li; Jiang Han; Zhiping Zhang
Journal:  Mar Drugs       Date:  2013-09-17       Impact factor: 5.118

5.  Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells.

Authors:  Mingrong Cheng; Hongzhi Xu; Yong Wang; Houxiang Chen; Bing He; Xiaoyan Gao; Yingchun Li; Jiang Han; Zhiping Zhang
Journal:  Drug Des Devel Ther       Date:  2013-10-25       Impact factor: 4.162

6.  Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics.

Authors:  Mingrong Cheng; Houxiang Chen; Yong Wang; Hongzhi Xu; Bing He; Jiang Han; Zhiping Zhang
Journal:  Int J Nanomedicine       Date:  2014-01-24

7.  Synthesis of liver-targeting dual-ligand modified GCGA/5-FU nanoparticles and their characteristics in vitro and in vivo.

Authors:  Mingrong Cheng; Xiaoyan Gao; Yong Wang; Houxiang Chen; Bing He; Yingchun Li; Jiang Han; Zhiping Zhang
Journal:  Int J Nanomedicine       Date:  2013-11-06

8.  Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells.

Authors:  Soyoon Park; Wesuk Kang; Dabin Choi; Bomin Son; Taesun Park
Journal:  Int J Mol Sci       Date:  2020-10-28       Impact factor: 5.923
  8 in total

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