PURPOSE: To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (T(M)), in hepatocellular carcinoma (HCC) patients following resection. METHODS: The infiltration of TAM and T(M) was assessed by immunohistochemistry in tissue microarray containing 302 HCC specimens. Correlations between TAM/T(M) infiltration and clinicopathologic features, disease-free survival (DFS) and overall survival (OS) were statistically analyzed. RESULTS: High TAM infiltration was associated with both improved DFS (P = 0.0021) and OS (P = 0.0481). Multivariate analysis identified TAM infiltration as independent prognostic factor for DFS (P = 0.004) and OS (P = 0.049). A second analysis clarified the synergistic effect of TAM&T(M) infiltration for DFS (P = 0.004) and OS (P = 0.040). CONCLUSIONS: Both TAM infiltration alone and concomitant infiltration of TAM&T(M) are associated with improved DFS/OS, suggesting that TAM could protect HCC patients from recurrence/metastasis and prolong survival by distinct mechanisms.
PURPOSE: To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (T(M)), in hepatocellular carcinoma (HCC) patients following resection. METHODS: The infiltration of TAM and T(M) was assessed by immunohistochemistry in tissue microarray containing 302 HCC specimens. Correlations between TAM/T(M) infiltration and clinicopathologic features, disease-free survival (DFS) and overall survival (OS) were statistically analyzed. RESULTS: High TAM infiltration was associated with both improved DFS (P = 0.0021) and OS (P = 0.0481). Multivariate analysis identified TAM infiltration as independent prognostic factor for DFS (P = 0.004) and OS (P = 0.049). A second analysis clarified the synergistic effect of TAM&T(M) infiltration for DFS (P = 0.004) and OS (P = 0.040). CONCLUSIONS: Both TAM infiltration alone and concomitant infiltration of TAM&T(M) are associated with improved DFS/OS, suggesting that TAM could protect HCCpatients from recurrence/metastasis and prolong survival by distinct mechanisms.
Authors: Johan Forssell; Ake Oberg; Maria L Henriksson; Roger Stenling; Andreas Jung; Richard Palmqvist Journal: Clin Cancer Res Date: 2007-03-01 Impact factor: 12.531
Authors: M Bortolami; C Venturi; L Giacomelli; R Scalerta; S Bacchetti; F Marino; A Floreani; M Lise; R Naccarato; F Farinati Journal: Dig Liver Dis Date: 2002-11 Impact factor: 4.088