Literature DB >> 18781044

Case of meningeal carcinomatosis with gastric cancer which manifested meningeal signs as the initial symptom; the palliative benefit of radiotherapy.

Takeshi Yamada1, Kiyonori Furukawa, Kimiyoshi Yokoi, Yoshiharu Ohaki, Susumu Okada, Takashi Tajiri.   

Abstract

A 53-year-old male presenting with anorexia, intermittent diplopia, general fatigue, headache and vertigo was admitted to our hospital. He was diagnosed as having gastric cancer by endoscopy of his upper gastrointestinal tract. Brain computed tomography (CT) showed no abnormalities, but magnetic resonance imaging (MRI) showed slight enhancement in the cerebellar sulcus. Cytological examination of cerebrospinal fluid revealed malignant cells. He became blind one week after hospitalization. We diagnosed his condition as meningeal carcinomatosis (MC) and started radiotherapy. His vision improved after four weeks of treatment, and then he became totally blind again. Since his general condition remained poor, we did not perform chemotherapy. He died on the 127th day of hospitalization. MC is a rare pathosis of gastric cancer in comparison with leukemia and malignant lymphoma. This disease does not often show characteristic pictorial images, and early diagnosis is difficult. Moreover, it usually manifests itself in its late stages after several months or more of treatment, and it is rare for MC to be present at the time of initial diagnosis. We present a case of gastric cancer with meningeal signs present when the primary tumors were diagnosed. Radiotherapy alleviated some of the symptoms, and the patient survived for as long as patients undergoing enforced chemotherapy.

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Year:  2008        PMID: 18781044     DOI: 10.1272/jnms.75.216

Source DB:  PubMed          Journal:  J Nippon Med Sch        ISSN: 1345-4676            Impact factor:   0.920


  5 in total

1.  Leptomeningeal carcinomatosis as the only manifestation of disease in recurrent gastroesophageal cancers.

Authors:  Syed Rizvi; Salman Fateh; Kamal K S Abbi; Yixing Jiang
Journal:  Gastrointest Cancer Res       Date:  2011-03

2.  Leptomeningeal carcinomatosis as the initial manifestation of gastric adenocarcinoma: a case report.

Authors:  Jian-Wen Guo; Xiao-Tian Zhang; Xiao-Sheng Chen; Xin-Chun Zhang; Guang-Juan Zheng; Bei-Ping Zhang; Ye-Feng Cai
Journal:  World J Gastroenterol       Date:  2014-02-28       Impact factor: 5.742

3.  Meningeal carcinomatosis: a metastasis from gastroesophageal junction adenocarcinoma.

Authors:  Tanya Dam; Aftab Mahmood; Kenneth Linville; Michael Bailey; Salim Surani
Journal:  Case Rep Med       Date:  2013-12-19

Review 4.  Intracranial hypertension as the primary symptom of gastric signet-ring cell carcinoma: A case report and literature review.

Authors:  Jiali Pu; Lingjia Xu; Xinzhen Yin; Baorong Zhang
Journal:  Medicine (Baltimore)       Date:  2016-08       Impact factor: 1.889

Review 5.  Optic neuritis as isolated manifestation of leptomeningeal carcinomatosis: a case report and systematic review of ocular manifestations of neoplastic meningitis.

Authors:  Silvia Lanfranconi; Paola Basilico; Ilaria Trezzi; Linda Borellini; Giulia Franco; Vittorio Civelli; Francesco Pallotti; Nereo Bresolin; Pierluigi Baron
Journal:  Neurol Res Int       Date:  2013-10-07
  5 in total

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