Sabina Zambon1, Giovanna Romanato2, Giovanni Sartore2, Raffaella Marin2, Luca Busetto2, Silvia Zanoni2, Franco Favretti3, Giuseppe Sergi2, Paola Fioretto2, Enzo Manzato4. 1. Department of Medical and Surgical Sciences, University of Padova, via Giustiniani, 2, 35128, Padova, Italy. sabina.zambon@unipd.it. 2. Department of Medical and Surgical Sciences, University of Padova, via Giustiniani, 2, 35128, Padova, Italy. 3. Department of Surgery, Regional Hospital of Vicenza, Vicenza, Italy. 4. Department of Medical and Surgical Sciences, University of Padova, and CNR Institute of Neurosciences, Center on Aging, Padova, Italy.
Abstract
BACKGROUND: Small dense low-density lipoprotein (LDL) are atherogenic particles frequently observed in obese patients. Fatty acids modulate LDL. Objective of this study was to determine the relations between plasma phospholipid fatty acid composition and the presence of small dense LDL particles in morbidly obese patients treated with laparoscopic gastric banding (LAGB). METHODS: Small dense LDL, plasma lipids, lipoproteins, apoproteins, and phospholipid fatty acid composition (a marker of dietary fatty acid intake) were quantified before and 12 months after surgery in four men and 11 women who were morbidly obese and (BMI > 40 kg/m(2)) eligible for surgery, consecutively treated with LAGB at the Department of Medical and Surgical Sciences of the University of Padova. RESULTS: BMI was 48.3 +/- 4.8 kg/m(2) before and 36.1 +/- 5.5 kg/m(2) after LAGB. Plasma triglycerides and apoprotein E levels significantly decreased, while HDL cholesterol significantly increased after LAGB. A reduction of small dense LDL with an increase of LDL relative flotation (0.34 +/- 0.04 before vs 0.38 +/- 0.03 after LAGB, p < 0.001) was also observed. These modifications were neither related to weight reduction nor to changes in phospholipid fatty acid composition, but they were associated to triglyceride reduction, which explained 76.7% of the LDL relative flotation variation. CONCLUSION: Weight loss obtained by LAGB in morbidly obese subjects was accompanied by triglyceride reduction, high-density lipoprotein increase, and an improvement of the atherogenic LDL profile. Triglyceride reduction, but not the extent of weight loss or dietary fatty acid modifications, is the determinant of modifications of LDL physical properties in these patients.
BACKGROUND: Small dense low-density lipoprotein (LDL) are atherogenic particles frequently observed in obesepatients. Fatty acids modulate LDL. Objective of this study was to determine the relations between plasma phospholipid fatty acid composition and the presence of small dense LDL particles in morbidly obesepatients treated with laparoscopic gastric banding (LAGB). METHODS: Small dense LDL, plasma lipids, lipoproteins, apoproteins, and phospholipid fatty acid composition (a marker of dietary fatty acid intake) were quantified before and 12 months after surgery in four men and 11 women who were morbidly obese and (BMI > 40 kg/m(2)) eligible for surgery, consecutively treated with LAGB at the Department of Medical and Surgical Sciences of the University of Padova. RESULTS: BMI was 48.3 +/- 4.8 kg/m(2) before and 36.1 +/- 5.5 kg/m(2) after LAGB. Plasma triglycerides and apoprotein E levels significantly decreased, while HDL cholesterol significantly increased after LAGB. A reduction of small dense LDL with an increase of LDL relative flotation (0.34 +/- 0.04 before vs 0.38 +/- 0.03 after LAGB, p < 0.001) was also observed. These modifications were neither related to weight reduction nor to changes in phospholipid fatty acid composition, but they were associated to triglyceride reduction, which explained 76.7% of the LDL relative flotation variation. CONCLUSION:Weight loss obtained by LAGB in morbidly obese subjects was accompanied by triglyceride reduction, high-density lipoprotein increase, and an improvement of the atherogenic LDL profile. Triglyceride reduction, but not the extent of weight loss or dietary fatty acid modifications, is the determinant of modifications of LDL physical properties in these patients.
Authors: Lars Sjöström; Anna-Karin Lindroos; Markku Peltonen; Jarl Torgerson; Claude Bouchard; Björn Carlsson; Sven Dahlgren; Bo Larsson; Kristina Narbro; Carl David Sjöström; Marianne Sullivan; Hans Wedel Journal: N Engl J Med Date: 2004-12-23 Impact factor: 91.245
Authors: B H Chung; J P Segrest; M J Ray; J D Brunzell; J E Hokanson; R M Krauss; K Beaudrie; J T Cone Journal: Methods Enzymol Date: 1986 Impact factor: 1.600
Authors: F Favretti; G B Cadiere; G Segato; J Himpens; L Busetto; F De Marchi; M Vertruyen; G Enzi; M De Luca; M Lise Journal: Obes Surg Date: 1997-08 Impact factor: 4.129
Authors: L Busetto; C Pisent; D Rinaldi; P L Longhin; G Segato; F De Marchi; M Foletto; F Favretti; M Lise; G Enzi Journal: Obes Surg Date: 2000-12 Impact factor: 4.129
Authors: Perrie F O'Tierney-Ginn; Melanie Gillingham; Jessica Fowler; Elizabeth Brass; Nicole E Marshall; Kent L Thornburg Journal: Reprod Sci Date: 2016-07-28 Impact factor: 3.060
Authors: Margaret A Stefater; Darleen A Sandoval; Adam P Chambers; Hilary E Wilson-Pérez; Susanna M Hofmann; Ronald Jandacek; Patrick Tso; Stephen C Woods; Randy J Seeley Journal: Gastroenterology Date: 2011-05-18 Impact factor: 22.682
Authors: Geraldine J Ooi; Arul Earnest; Lisa Doyle; Cheryl Laurie; John M Wentworth; Ken Sikaris; Carel W le Roux; Paul R Burton; Paul E O'Brien; Wendy A Brown Journal: Obes Surg Date: 2018-05 Impact factor: 4.129
Authors: E Griffo; G Nosso; R Lupoli; M Cotugno; G Saldalamacchia; G Vitolo; L Angrisani; P P Cutolo; A A Rivellese; B Capaldo Journal: Obes Surg Date: 2014-05 Impact factor: 4.129
Authors: A S Shah; T Jenkins; Z Gao; S R Daniels; E M Urbina; S Kirk; R Siegel; T H Inge Journal: Int J Obes (Lond) Date: 2017-06-09 Impact factor: 5.095
Authors: Rahul Yadav; Salam Hama; Yifen Liu; Tarza Siahmansur; Jonathan Schofield; Akheel A Syed; Michael France; Philip Pemberton; Safwaan Adam; Jan Hoong Ho; Reza Aghamohammadzadeh; Shaishav Dhage; Rachelle Donn; Rayaz A Malik; John P New; Maria Jeziorska; Paul Durrington; Basil A Ammori; Handrean Soran Journal: Front Immunol Date: 2017-11-15 Impact factor: 7.561
Authors: Stephen J Hierons; Kazim Abbas; Amélie I S Sobczak; Michela Cerone; Terry K Smith; Ramzi A Ajjan; Alan J Stewart Journal: Sci Rep Date: 2022-09-12 Impact factor: 4.996