Literature DB >> 18778939

Triazole oxytocin antagonists: identification of aryl ether replacements for a biaryl substituent.

Alan Brown1, Lindsay Brown, T Bruce Brown, Andrew Calabrese, Dave Ellis, Nicholas Puhalo, Chris R Smith, Olga Wallace, Lesa Watson.   

Abstract

Several potent aryl ether/triazole oxytocin antagonists are described. The lead compound in this series had significantly improved aqueous solubility over related systems containing a biaryl substituent.

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Year:  2008        PMID: 18778939     DOI: 10.1016/j.bmcl.2008.08.066

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood-Brain Barrier Penetration.

Authors:  Xin Li; Zhigao Zhang; Yang Chen; Hong Wan; Jiakang Sun; Bin Wang; Bingqiang Feng; Bing Hu; Xingxing Shi; Jun Feng; Lei Zhang; Feng He; Chang Bai; Lianshan Zhang; Weikang Tao
Journal:  ACS Med Chem Lett       Date:  2019-05-29       Impact factor: 4.345

2.  Dialkyl Ether Formation at High-Valent Nickel.

Authors:  Franck Le Vaillant; Edward J Reijerse; Markus Leutzsch; Josep Cornella
Journal:  J Am Chem Soc       Date:  2020-11-03       Impact factor: 15.419

  2 in total

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