Literature DB >> 18778769

Hepatocellular carcinoma and the ubiquitin-proteasome system.

Simon P Dawson1.   

Abstract

Hepatocellular carcinoma is one of the largest causes of cancer-related deaths worldwide for which there are very limited treatment options that are currently effective. The ubiquitin-proteasome system has rapidly become acknowledged as both critical for normal cellular function and a frequent target of de-regulation leading to disease. This review appraises the evidence linking the ubiquitin-proteasome system with this devastatingly intractable cancer and asks whether it may prove to be fertile ground for the development of novel therapeutic interventions against hepatocellular carcinoma.

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Year:  2008        PMID： 18778769     DOI： 10.1016/j.bbadis.2008.08.003

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  18 in total

1.  Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers.

Authors:  Hongxing Zhang; Yun Zhai; Zhibin Hu; Chen Wu; Ji Qian; Weihua Jia; Fuchao Ma; Wenfeng Huang; Lixia Yu; Wei Yue; Zhifu Wang; Peiyao Li; Yang Zhang; Renxiang Liang; Zhongliang Wei; Ying Cui; Weimin Xie; Mi Cai; Xinsen Yu; Yunfei Yuan; Xia Xia; Xiumei Zhang; Hao Yang; Wei Qiu; Jingmin Yang; Feng Gong; Minshan Chen; Hongbing Shen; Dongxin Lin; Yi-Xin Zeng; Fuchu He; Gangqiao Zhou
Journal:  Nat Genet       Date:  2010-08-01       Impact factor: 38.330

2.  FXR-Gankyrin axis is involved in development of pediatric liver cancer.

Authors:  Leila Valanejad; Kyle Lewis; Mary Wright; Yanjun Jiang; Amber D'Souza; Rebekah Karns; Rachel Sheridan; Anita Gupta; Kevin Bove; David Witte; James Geller; Gregory Tiao; David L Nelson; Lubov Timchenko; Nikolai Timchenko
Journal:  Carcinogenesis       Date:  2017-07-01       Impact factor: 4.944

Review 3.  Neddylation, a novel paradigm in liver cancer.

Authors:  Teresa Cardoso Delgado; Lúcia Barbier-Torres; Imanol Zubiete-Franco; Fernando Lopitz-Otsoa; Marta Varela-Rey; David Fernández-Ramos; María-Luz Martínez-Chantar
Journal:  Transl Gastroenterol Hepatol       Date:  2018-06-30

4.  RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.

Authors:  Kyle Lewis; Leila Valanejad; Ashley Cast; Mary Wright; Christina Wei; Polina Iakova; Lauren Stock; Rebekah Karns; Lubov Timchenko; Nikolai Timchenko
Journal:  Mol Cell Biol       Date:  2017-07-28       Impact factor: 4.272

Review 5.  Intracellular signaling and hepatocellular carcinoma.

Authors:  Polina Iakova; Lubov Timchenko; Nikolai A Timchenko
Journal:  Semin Cancer Biol       Date:  2010-09-17       Impact factor: 15.707

6.  Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice.

Authors:  Guo-Li Wang; Xiurong Shi; Simon Haefliger; Jingling Jin; Angela Major; Polina Iakova; Milton Finegold; Nikolai A Timchenko
Journal:  J Clin Invest       Date:  2010-07       Impact factor: 14.808

7.  Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer.

Authors:  Yanjun Jiang; Polina Iakova; Jingling Jin; Emily Sullivan; Vladislav Sharin; Il-Hwa Hong; Sayee Anakk; Angela Mayor; Gretchen Darlington; Milton Finegold; David Moore; Nikolai A Timchenko
Journal:  Hepatology       Date:  2013-02-15       Impact factor: 17.425

8.  The role and regulatory mechanism of 14-3-3 sigma in human breast cancer.

Authors:  SeungSang Ko; Ji Young Kim; Joon Jeong; Jong Eun Lee; Woo Ick Yang; Woo Hee Jung
Journal:  J Breast Cancer       Date:  2014-09-30       Impact factor: 3.588

9.  Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage.

Authors:  Hang T Pham; Tram T T Nguyen; Lap P Nguyen; Sang-Seop Han; Yun-Sook Lim; Soon B Hwang
Journal:  J Virol       Date:  2019-01-04       Impact factor: 5.103

10.  Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.

Authors:  Daoxiong Lei; Faqian Li; Huabo Su; Jinbao Liu; Ning Wei; Xuejun Wang
Journal:  PLoS One       Date:  2013-07-01       Impact factor: 3.240
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