Literature DB >> 18778193

Colostrinin: a naturally occurring compound derived from mammalian colostrum with efficacy in treatment of neurodegenerative diseases, including Alzheimer's.

Michael G Stewart1.   

Abstract

Neurodegenerative illnesses such as Alzheimer's disease and their debilitating effects pose a major problem as their incidence increases. Although clinical management of neurodegenerative diseases usually involves symptomatic treatment, Colostrinin() (CLN), which has efficacy in counteracting neural degradation and in stimulating neural growth, might prove to be a more effective means to deal with the causes of Alzheimer's and other neurodegenerative diseases. Evidence for the clinical efficacy of CLN is discussed and recent data examined showing the remarkable ability of CLN to reduce oxidative stress, prevent beta-amyloid aggregation and prolong the lifespan in a laboratory model of premature ageing. An increasingly important application for CLN has been as a nutraceutical product for use in the early stages of cognitive decline in humans, with licensed use in North America and Australia, and now in Europe. It might also be of considerable utility as a veterinary nutraceutical for companion animals.

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Year:  2008        PMID: 18778193     DOI: 10.1517/14656566.9.14.2553

Source DB:  PubMed          Journal:  Expert Opin Pharmacother        ISSN: 1465-6566            Impact factor:   3.889


  3 in total

1.  New insight into mode of action of Colostrinin.

Authors:  Michael G Stewart
Journal:  J Nutr Health Aging       Date:  2010-04       Impact factor: 4.075

2.  Amyloid-beta induced CA1 pyramidal cell loss in young adult rats is alleviated by systemic treatment with FGL, a neural cell adhesion molecule-derived mimetic peptide.

Authors:  Nicola J Corbett; Paul L Gabbott; Boris Klementiev; Heather A Davies; Frances M Colyer; Tatiana Novikova; Michael G Stewart
Journal:  PLoS One       Date:  2013-08-09       Impact factor: 3.240

Review 3.  Breast Milk: A Source of Functional Compounds with Potential Application in Nutrition and Therapy.

Authors:  Cristina Sánchez; Luis Franco; Patricia Regal; Alexandre Lamas; Alberto Cepeda; Cristina Fente
Journal:  Nutrients       Date:  2021-03-22       Impact factor: 5.717

  3 in total

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