PURPOSE: To investigate the utility of apparent diffusion coefficient (ADC) values for discriminating tumor in patients with prostate cancer from normal prostatic tissues in healthy adult men, and to identify correlations between ADC and histologic grade of prostate cancer. MATERIALS AND METHODS: A total of 125 healthy male volunteers (mean age, 60 years; range, 50-86 years) and 90 prostate cancer patients (mean age, 71 years; range, 51-88 years) underwent diffusion-weighted imaging (DWI) of the prostate with a single-shot echo-planar imaging sequence using b-factors of 0 and 800 sec/mm2. ADC was measured from two locations in the peripheral zone (PZ) and two locations in the central gland (CG) in normal subjects, and tumor locations of PZ or transition zone (TZ) in patients with prostate cancer. RESULTS: Mean ADC values of tumor regions in both PZ (1.02+/-0.25x10(-3) mm2/sec) and TZ (0.94+/-0.21x10(-3) mm2/sec) were significantly lower than those in the corresponding normal regions (1.80+/-0.27x10(-3) mm2/sec and 1.34+/-0.14x10(-3) mm2/sec, respectively) (P<0.0001 each). Furthermore, a significant negative correlation was identified between ADC in PZ cancer and tumor Gleason score (rho=-0.497, P<0.0001). CONCLUSION: ADC values appear to provide acceptable diagnostic accuracy in both PZ and TZ. Copyright (c) 2008 Wiley-Liss, Inc.
PURPOSE: To investigate the utility of apparent diffusion coefficient (ADC) values for discriminating tumor in patients with prostate cancer from normal prostatic tissues in healthy adult men, and to identify correlations between ADC and histologic grade of prostate cancer. MATERIALS AND METHODS: A total of 125 healthy male volunteers (mean age, 60 years; range, 50-86 years) and 90 prostate cancerpatients (mean age, 71 years; range, 51-88 years) underwent diffusion-weighted imaging (DWI) of the prostate with a single-shot echo-planar imaging sequence using b-factors of 0 and 800 sec/mm2. ADC was measured from two locations in the peripheral zone (PZ) and two locations in the central gland (CG) in normal subjects, and tumor locations of PZ or transition zone (TZ) in patients with prostate cancer. RESULTS: Mean ADC values of tumor regions in both PZ (1.02+/-0.25x10(-3) mm2/sec) and TZ (0.94+/-0.21x10(-3) mm2/sec) were significantly lower than those in the corresponding normal regions (1.80+/-0.27x10(-3) mm2/sec and 1.34+/-0.14x10(-3) mm2/sec, respectively) (P<0.0001 each). Furthermore, a significant negative correlation was identified between ADC in PZ cancer and tumor Gleason score (rho=-0.497, P<0.0001). CONCLUSION: ADC values appear to provide acceptable diagnostic accuracy in both PZ and TZ. Copyright (c) 2008 Wiley-Liss, Inc.
Authors: Michael Quentin; Lars Schimmöller; Christian Arsov; Robert Rabenalt; Gerald Antoch; Peter Albers; Dirk Blondin Journal: Eur Radiol Date: 2013-08-31 Impact factor: 5.315
Authors: Sonia Gaur; Stephanie Harmon; Lauren Rosenblum; Matthew D Greer; Sherif Mehralivand; Mehmet Coskun; Maria J Merino; Bradford J Wood; Joanna H Shih; Peter A Pinto; Peter L Choyke; Baris Turkbey Journal: AJR Am J Roentgenol Date: 2018-05-07 Impact factor: 3.959
Authors: Sonia Gaur; Stephanie Harmon; Rajan T Gupta; Daniel J Margolis; Nathan Lay; Sherif Mehralivand; Maria J Merino; Bradford J Wood; Peter A Pinto; Joanna H Shih; Peter L Choyke; Baris Turkbey Journal: Acad Radiol Date: 2018-04-25 Impact factor: 3.173
Authors: Tan B Nguyen; Alexander Ushinsky; Albert Yang; Michael Nguyentat; Sara Fardin; Edward Uchio; Chandana Lall; Thomas Lee; Roozbeh Houshyar Journal: Br J Radiol Date: 2018-06-21 Impact factor: 3.039