Literature DB >> 18777452

Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence.

D LeRoith1, R Novosyadlyy, E J Gallagher, D Lann, A Vijayakumar, S Yakar.   

Abstract

Both obesity and Type 2 diabetes are independently associated with an increased risk of developing cancer and an increased mortality. The etiology is yet to be determined but insulin resistance and hyperinsulinemia maybe important factors. Hyperglycemia, hyperlipidemia and inflammatory cytokines in addition to the insulin-like growth factors are also possible factors involved in the process.

Entities:  

Mesh：

Year:  2008        PMID： 18777452     DOI： 10.1055/s-2008-1081488

Source DB:  PubMed          Journal:  Exp Clin Endocrinol Diabetes        ISSN： 0947-7349            Impact factor:   2.949


  45 in total

Review 1.  Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials.

Authors:  Catherine D Mao; Stephen W Byers
Journal:  Crit Rev Eukaryot Gene Expr       Date:  2011       Impact factor: 1.807

2.  Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition.

Authors:  Sang Yoon Park; Hyun Sil Kim; Nam Hee Kim; Suena Ji; So Young Cha; Jeong Gu Kang; Ichiro Ota; Keiji Shimada; Noboru Konishi; Hyung Wook Nam; Soon Won Hong; Won Ho Yang; Jürgen Roth; Jong In Yook; Jin Won Cho
Journal:  EMBO J       Date:  2010-10-19       Impact factor: 11.598

3.  Candy consumption in childhood is not predictive of weight, adiposity measures or cardiovascular risk factors in young adults: the Bogalusa Heart Study.

Authors:  C E O'Neil; T A Nicklas; Y Liu; G S Berenson
Journal:  J Hum Nutr Diet       Date:  2013-12-30       Impact factor: 3.089

Review 4.  Sirtuins and the Metabolic Hurdles in Cancer.

Authors:  Natalie J German; Marcia C Haigis
Journal:  Curr Biol       Date:  2015-06-29       Impact factor: 10.834

Review 5.  Adipokine Pattern After Bariatric Surgery: Beyond the Weight Loss.

Authors:  Gian Franco Adami; Nicola Scopinaro; Renzo Cordera
Journal:  Obes Surg       Date:  2016-11       Impact factor: 4.129

6.  Adipocytes as immune regulatory cells.

Authors:  Silvana A Vielma; Richard L Klein; Corinne A Levingston; M Rita I Young
Journal:  Int Immunopharmacol       Date:  2013-04-13       Impact factor: 4.932

7.  Insulin resistance and increased risk for malignant neoplasms: confounding of the data on insulin glargine.

Authors:  J M Nagel; U Mansmann; K Wegscheider; J Röhmel
Journal:  Diabetologia       Date:  2009-09-24       Impact factor: 10.122

8.  Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.

Authors:  Ming Zhao; Zhu-li Wan; Linda Whittaker; Bin Xu; Nelson B Phillips; Panayotis G Katsoyannis; Faramarz Ismail-Beigi; Jonathan Whittaker; Michael A Weiss
Journal:  J Biol Chem       Date:  2009-09-22       Impact factor: 5.157

9.  Associations of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry.

Authors:  Xilin Yang; Gary T C Ko; Wing Yee So; Ronald C W Ma; Linda W L Yu; Alice P S Kong; Hailu Zhao; Chun-Chung Chow; Peter C Y Tong; Juliana C N Chan
Journal:  Diabetes       Date:  2010-02-25       Impact factor: 9.461

10.  Longitudinal associations of blood markers of insulin and glucose metabolism and cancer mortality in the third National Health and Nutrition Examination Survey.

Authors:  Niyati Parekh; Yong Lin; Richard B Hayes; Jeanine B Albu; Grace L Lu-Yao
Journal:  Cancer Causes Control       Date:  2010-01-23       Impact factor: 2.506
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