Literature DB >> 18776739

Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer.

Yang Shen1, Dan-Dan Li, Lin-Lin Wang, Rong Deng, Xiao-Feng Zhu.   

Abstract

Some studies have shown that the change of autophagic capacity may correlate with malignant transformation. Our study was designed to investigate the expression and significance of two autophagy-related proteins, microtubule-associated protein 1 light chain 3 (LC3) and Beclin 1 in the tumorigenesis and development of epithelial ovarian carcinoma. We observed that the positive expression of LC3 and Beclin 1 was significantly higher in the samples of benign and borderline ovarian tumors than those in malignant epithelial ovarian cancers. The expression of LC3 and Beclin 1 was associated with FIGO stage and histological grade. No significant relationship was observed between age and histological grade. However, we observed that the expression of LC3 was not related to Beclin 1. Therefore, the decrease of autophagic capacity may be related to tumorigenesis and development of epithelial ovarian cancer.

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Year:  2008        PMID： 18776739     DOI： 10.4161/auto.6827

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  63 in total

1.  Expression of Beclin 1 and LC3 in FIGO stage I-II cervical squamous cell carcinoma and relationship to survival.

Authors:  Weipei Zhu; Xiaohong Pan; Feng Li; Yongshen Zhang; Xueguan Lu
Journal:  Tumour Biol       Date:  2012-05-25

2.  Expression pattern of autophagy-related markers in non-metastatic clear cell renal cell carcinoma: association with disease recurrence following radical nephrectomy.

Authors:  Masatomo Nishikawa; Hideaki Miyake; Bing Liu; Masato Fujisawa
Journal:  J Cancer Res Clin Oncol       Date:  2015-02-01       Impact factor: 4.553

Review 3.  Linking Autophagy and the Dysregulated NFκB/ SNAIL/YY1/RKIP/PTEN Loop in Cancer: Therapeutic Implications.

Authors:  Benjamin Bonavida
Journal:  Crit Rev Oncog       Date:  2018

Review 4.  Biological determinants of radioresistance and their remediation in pancreatic cancer.

Authors:  Parthasarathy Seshacharyulu; Michael J Baine; Joshua J Souchek; Melanie Menning; Sukhwinder Kaur; Ying Yan; Michel M Ouellette; Maneesh Jain; Chi Lin; Surinder K Batra
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2017-02-27       Impact factor: 10.680

5.  MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy.

Authors:  Zhenyou Zou; Linping Wu; Hanying Ding; Yang Wang; Yaqin Zhang; Xuejiao Chen; Xi Chen; Chen-Yu Zhang; Qipeng Zhang; Ke Zen
Journal:  J Biol Chem       Date:  2011-12-08       Impact factor: 5.157

6.  Decreased expression of light chain 3 (LC3) increased the risk of distant metastasis in triple-negative breast cancer.

Authors:  Jie-Hua He; Rong-Zhen Luo; Mu-Yan Cai; Mei Li; Jia-Bing Lu; Zhong-Yu Yuan
Journal:  Med Oncol       Date:  2013-01-24       Impact factor: 3.064

7.  Prognostic significance of Beclin-1 expression in laryngeal squamous cell carcinoma.

Authors:  Li Huang; Shuang Wang; Shi-Sheng Li; Xin-Ming Yang
Journal:  Pathol Oncol Res       Date:  2013-05-19       Impact factor: 3.201

8.  Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells.

Authors:  Hua Zhu; Hao Wu; Xiuping Liu; Biao Li; Yun Chen; Xingcong Ren; Chang-Gong Liu; Jin-Ming Yang
Journal:  Autophagy       Date:  2009-08-20       Impact factor: 16.016

Review 9.  Autophagy in cellular growth control.

Authors:  Richard C Wang; Beth Levine
Journal:  FEBS Lett       Date:  2010-01-22       Impact factor: 4.124

10.  Overexpression of tumor necrosis factor receptor-associated protein 1 (TRAP1) are associated with poor prognosis of epithelial ovarian cancer.

Authors:  Qingjie Lv; Hanxue Sun; Chengcheng Cao; Bo Gao; Yafei Qi
Journal:  Tumour Biol       Date:  2015-09-25
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