Literature DB >> 187766

Natural occurrence of tumors in mouse strains with different xenotropic and ecotropic endogenous viruses.

G J Kelloff, R L Peters, R M Donahoe, J R Stephenson, S A Aaronson.   

Abstract

Natural tumor incidence and type C virus expression in HIH Swiss and BALB/c mice were investigated. The BALB/c mice showed a moderate incidence of lymphoreticular tumors containing infectious ecotropic virus. A second class of lymphoreticular tumors occurred with approximately the same incidence in both strains; though infectious virus could not be isolated from it, it contained the antigens of a common xenotropic virus. These xenotropic viral antigens were found in all NIH Swiss and BALB/c tumors examined and in normal hematopoietic tissues as well. The relationship between different classes of endogenous viruses and tumor development was discussed.

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Year:  1976        PMID: 187766     DOI: 10.1093/jnci/57.1.85

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN: 0027-8874            Impact factor:   13.506


  4 in total

1.  Leukemogenicity and cell transformation mechanisms in vitro by Gross murine leukemia virus: analysis of virus subpopulations.

Authors:  K Hamada; K Yanagihara; K Kamiya; T Seyama; K Yokoro
Journal:  J Virol       Date:  1981-04       Impact factor: 5.103

2.  Immunoprevention of x-ray-induced leukemias in the C57BL mouse.

Authors:  R L Peters; B Sass; J R Stephenson; I K Al-Ghazzouli; S Hino; R M Donahoe; M Kende; S A Aaronson; G J KElloff
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

3.  Chemical transformation of rat cells infected with xenotropic type-C RNA virus and its suppression by virus-specific antiserum.

Authors:  P J Price; W A Suk; R L Peters; R V Gilden; R J Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

4.  Naturally occurring lymphocyte-mediated immunity to endogenous type-C virus in the mouse. Blocking of the lymphocyte reactivity with antisera to the virus.

Authors:  M Kende; R Hill; M Dinowitz; J R Stephenson; G J Kelloff
Journal:  J Exp Med       Date:  1979-02-01       Impact factor: 14.307

  4 in total

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