Literature DB >> 18776297

A click chemistry approach towards nucleic acid major groove functionalization.

Nicolai K Andersen1, Lucie Spácilová, Michael D Jensen, Petr Kocalka, Frank Jensen, Poul Nielsen.   

Abstract

A synthetic strategy towards new aromatic nucleoside derivatives introducing additional aromatic functionality placed in the major groove of a modified DNA duplex is presented. The functionalities are introduced using Click Chemistry conditions and found to increase the overall duplex stability.

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Year:  2008        PMID: 18776297     DOI: 10.1093/nass/nrn076

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser (Oxf)        ISSN: 0261-3166


  1 in total

1.  Hydrogelation abilities of nucleobase-modified cytidines possessing substituted triazoles.

Authors:  David W Dodd; Nathan D Jones; Robert He Hudson
Journal:  Artif DNA PNA XNA       Date:  2010-10
  1 in total

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