Literature DB >> 18776289

Unlocked nucleic acid (UNA) and UNA derivatives: thermal denaturation studies.

Troels Bundgaard Jensen1, Niels Langkjaer, Jesper Wengel.   

Abstract

A study on the thermal stability of duplexes formed between unlocked nucleic acid (UNA) modified DNA and RNA oligonucleotides and complementary DNA and RNA is presented. The acyclic UNA monomers are shown to induce a decrease in duplex thermal stability.

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Year:  2008        PMID： 18776289     DOI： 10.1093/nass/nrn068

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser (Oxf)        ISSN： 0261-3166


  7 in total

1.  RNAi-based therapeutics targeting survivin and PLK1 for treatment of bladder cancer.

Authors:  Shaguna Seth; Yoshiyuki Matsui; Kathy Fosnaugh; Yan Liu; Narendra Vaish; Roger Adami; Pierrot Harvie; Rachel Johns; Gregory Severson; Tod Brown; Akihide Takagi; Susan Bell; Yan Chen; Feng Chen; Tianying Zhu; Renata Fam; Iwona Maciagiewicz; Erin Kwang; Michael McCutcheon; Ken Farber; Patrick Charmley; Michael E Houston; Alan So; Michael V Templin; Barry Polisky
Journal:  Mol Ther       Date:  2011-03-01       Impact factor: 11.454

2.  Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides.

Authors:  Anna Pasternak; Jesper Wengel
Journal:  Nucleic Acids Res       Date:  2010-06-18       Impact factor: 16.971

3.  Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer.

Authors:  Anna Pasternak; Frank J Hernandez; Lars M Rasmussen; Birte Vester; Jesper Wengel
Journal:  Nucleic Acids Res       Date:  2010-09-24       Impact factor: 16.971

4.  Locked and unlocked nucleosides in functional nucleic acids.

Authors:  Holger Doessing; Birte Vester
Journal:  Molecules       Date:  2011-05-27       Impact factor: 4.411

5.  Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.

Authors:  Denise M Kenski; Abby J Cooper; Jenny J Li; Aarron T Willingham; Henry J Haringsma; Tracy A Young; Nelly A Kuklin; Jeffrey J Jones; Mark T Cancilla; Daniel R McMasters; Melina Mathur; Alan B Sachs; W Michael Flanagan
Journal:  Nucleic Acids Res       Date:  2009-11-16       Impact factor: 16.971

6.  siRNA-optimized Modifications for Enhanced In Vivo Activity.

Authors:  Denise M Kenski; Gabor Butora; Aarron T Willingham; Abby J Cooper; Wenlang Fu; Ning Qi; Ferdie Soriano; Ian W Davies; W Michael Flanagan
Journal:  Mol Ther Nucleic Acids       Date:  2012-01-24       Impact factor: 10.183

Review 7.  Deciphering Non-coding RNAs in Cardiovascular Health and Disease.

Authors:  Anindita Das; Arun Samidurai; Fadi N Salloum
Journal:  Front Cardiovasc Med       Date:  2018-07-02
  7 in total

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