Literature DB >> 18776246

Click chemistry and oligonucleotides: how a simple reaction can do so much.

François Morvan1, Albert Meyer, Gwladys Pourceau, Sébastien Vidal, Yann Chevolot, Eliane Souteyrand, Jean-Jacques Vasseur.   

Abstract

Copper catalyzed Alkyne Azide 1,3-dipolar cycloaddition (CuAAC) "click reaction" was applied for the construction of oligonucleotide conjugates, circular objects and phosphodiester glyco-clusters. To this end, several strategies were developed to introduce either alkyne or azide functions into an oligonucleotide.

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Year:  2008        PMID: 18776246     DOI: 10.1093/nass/nrn024

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser (Oxf)        ISSN: 0261-3166


  1 in total

1.  MiL-FISH: Multilabeled Oligonucleotides for Fluorescence In Situ Hybridization Improve Visualization of Bacterial Cells.

Authors:  Mario P Schimak; Manuel Kleiner; Silke Wetzel; Manuel Liebeke; Nicole Dubilier; Bernhard M Fuchs
Journal:  Appl Environ Microbiol       Date:  2015-10-16       Impact factor: 4.792

  1 in total

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