S H Song1, C A Hardisty. 1. Diabetes Centre, Northern General Hospital, Sheffield, UK. soon_song@hotmail.com
Abstract
BACKGROUND: Measurement of body weight with body mass index (BMI) is often utilized to stratify cardiovascular disease (CVD) risk. AIM: To determine CVD risk profile and disease burden in subjects with type 2 diabetes mellitus (T2DM) across different categories of body weight as defined by BMI. DESIGN: Prospective observational study. METHODS: CVD risk including metabolic syndrome (MetS) and prevalence of macrovascular complications were determined for each category of body weight as defined by the World Health Organisation (WHO) classification. RESULTS: A total of 390 subjects were included in this study of which 35.9% were non-obese (BMI <30 kg/m(2)). Although increasing obesity as defined by BMI was associated with higher prevalence of central abdominal obesity, hypertension and MetS (P < 0.05), dyslipidaemia and macrovascular complications were not significantly different across the various body weight categories (P = NS). Similar observation was seen in non-obese (BMI <30 kg/m(2)) and obese subjects (BMI >30 kg/m(2)). Among non-obese (including normal weight) cohort, the majority of these subjects had adverse CVD risk profile including presence of at least two co-existing risk factors. CONCLUSION: Subjects with T2DM possess adverse CVD risk factors with significant burden of macrovascular disease irrespective of their baseline body weight.
BACKGROUND: Measurement of body weight with body mass index (BMI) is often utilized to stratify cardiovascular disease (CVD) risk. AIM: To determine CVD risk profile and disease burden in subjects with type 2 diabetes mellitus (T2DM) across different categories of body weight as defined by BMI. DESIGN: Prospective observational study. METHODS: CVD risk including metabolic syndrome (MetS) and prevalence of macrovascular complications were determined for each category of body weight as defined by the World Health Organisation (WHO) classification. RESULTS: A total of 390 subjects were included in this study of which 35.9% were non-obese (BMI <30 kg/m(2)). Although increasing obesity as defined by BMI was associated with higher prevalence of central abdominal obesity, hypertension and MetS (P < 0.05), dyslipidaemia and macrovascular complications were not significantly different across the various body weight categories (P = NS). Similar observation was seen in non-obese (BMI <30 kg/m(2)) and obese subjects (BMI >30 kg/m(2)). Among non-obese (including normal weight) cohort, the majority of these subjects had adverse CVD risk profile including presence of at least two co-existing risk factors. CONCLUSION: Subjects with T2DM possess adverse CVD risk factors with significant burden of macrovascular disease irrespective of their baseline body weight.
Authors: Shijie Li; Paul Kievit; Anna-Karin Robertson; Ganesh Kolumam; Xiumin Li; Karin von Wachenfeldt; Christine Valfridsson; Sherry Bullens; Ilhem Messaoudi; Lindsay Bader; Kyra J Cowan; Amrita Kamath; Nicholas van Bruggen; Stuart Bunting; Björn Frendéus; Kevin L Grove Journal: Mol Metab Date: 2013-06-11 Impact factor: 7.422
Authors: Koert N J Burger; Joline W J Beulens; Yvonne T van der Schouw; Ivonne Sluijs; Annemieke M W Spijkerman; Diewertje Sluik; Heiner Boeing; Rudolf Kaaks; Birgit Teucher; Claus Dethlefsen; Kim Overvad; Anne Tjønneland; Cecilie Kyrø; Aurelio Barricarte; Benedetta Bendinelli; Vittorio Krogh; Rosario Tumino; Carlotta Sacerdote; Amalia Mattiello; Peter M Nilsson; Marju Orho-Melander; Olov Rolandsson; José María Huerta; Francesca Crowe; Naomi Allen; Ute Nöthlings Journal: PLoS One Date: 2012-08-23 Impact factor: 3.240