Literature DB >> 18775585

Design, synthesis, structure-activity relationship and antibacterial activity series of novel imidazo fused quinolone carboxamides.

G Venkat Reddy1, S Ravi Kanth, D Maitraie, B Narsaiah, P Shanthan Rao, K Hara Kishore, U S N Murthy, B Ravi, B Ashok Kumar, T Parthasarathy.   

Abstract

A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated against antibacterial activity. 1,8 Imidazo fused quinolones exhibit moderate antibacterial activity. Molecular modeling studies were carried out to optimize the pharmacophore.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18775585     DOI： 10.1016/j.ejmech.2008.07.024

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  3 in total

1.  Crystal structures of 1-(4-chloro-phen-yl)-4-(4-methyl-phen-yl)-2,5-dioxo-1,2,5,6,7,8-hexa-hydro-quinoline-3-carb-oxy-lic acid and 4-(4-meth-oxy-phen-yl)-1-(4-methyl-phen-yl)-2,5-dioxo-1,2,5,6,7,8-hexa-hydro-quinoline-3-carbo-nitrile.

Authors:  Omyma A Abd Allah; Manpreet Kaur; Mehmet Akkurt; Shaaban K Mohamed; Asmaa H A Tamam; Sahar M I Elgarhy; Jerry P Jasinski
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2021-03-05

2.  Antituberculosis activity of the molecular libraries screening center network library.

Authors:  Joseph A Maddry; Subramaniam Ananthan; Robert C Goldman; Judith V Hobrath; Cecil D Kwong; Clinton Maddox; Lynn Rasmussen; Robert C Reynolds; John A Secrist; Melinda I Sosa; E Lucile White; Wei Zhang
Journal:  Tuberculosis (Edinb)       Date:  2009-09-26       Impact factor: 3.131

3.  Design, synthesis, molecular docking, and antibacterial evaluation of some novel flouroquinolone derivatives as potent antibacterial agent.

Authors:  Mehul M Patel; Laxman J Patel
Journal:  ScientificWorldJournal       Date:  2014-12-09
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.