Literature DB >> 18774863

11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum.

Ruengrit Sappapan1, Damrong Sommit, Nattaya Ngamrojanavanich, Somchai Pengpreecha, Suthep Wiyakrutta, Nongluksna Sriubolmas, Khanitha Pudhom.   

Abstract

A new analogue of monocerin, 11-hydroxymonocerin (2), along with monocerin (1) and 12-hydroxymonocerin (3) were isolated from cultures of Exserohilum rostratum, a fungal strain endophytic in Stemona sp. The structure of 2 was determined by analysis of NMR and MS data and by comparison of spectroscopic data to those of 1. Monocerin (1) and 11-hydroxymonocerin (2) displayed activity against Plasmodium falciparum (K1, multidrug-resistant strain) with IC50 values of 0.68 and 7.70 microM, respectively. None of the compounds were cytotoxic against any of the tumor cell lines tested.

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Year:  2008        PMID： 18774863     DOI： 10.1021/np8004024

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

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5.  Antiprotozoal and Antibacterial Activity of Ravenelin, a Xanthone Isolated from the Endophytic Fungus Exserohilum rostratum.

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  6 in total

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