[Severe hematogenous contact dermatitis after oral nickel exposition].

A 19-year-old woman with known strong contact sensitization to nickel sulfate presented with persistent periumbilical eczema even though she had been careful to avoid exposure to the allergen. She had childhood atopic dermatitis which had been latent but had flared a year previously, presenting as flexural eczema. Double-blind placebo-controlled oral challenge with 5 mg nickel revealed a hematogenous contact dermatitis, accompanied by fever and malaise. It resolved quickly after treatment with systemic steroids and antihistamines. The possibility of hematogenous contact dermatitis should be considered in patients with strong delayed-type hypersensitivity suffering from persistent or relapsing eczema.

RCT Entities:   Population Interventions Outcomes