| Literature DB >> 18771917 |
Eunkyung Kim1, Chan Sun Park, Taedong Han, Myung-Ho Bae, Wonee Chong, Choong Hyun Lee, Young Ah Shin, Byung-Nak Ahn, Mi Kyung Kim, Chang Yell Shin, Moon Ho Son, Jin Kwan Kim, Ho Sang Moon, Hyun Joo Shim, Eun Jung Kim, Soon Hoe Kim, Joong In Lim, Chun Ho Lee.
Abstract
Aryl-tetrahydropyridine derivatives were prepared and their PPARalpha/gamma dual agonistic activities were evaluated. Among them, compound (S)-5b was identified as a potent PPARalpha/gamma dual agonist with an EC(50) of 1.73 and 0.64 microM in hPPARalpha and gamma, respectively. In diabetic (db/db) mice, compound (S)-5b showed good glucose lowering efficacy and favorable pharmacokinetic properties.Entities:
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Year: 2008 PMID： 18771917 DOI： 10.1016/j.bmcl.2008.08.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823