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Literature DB >> 18770576

Hamster model of leptospirosis.

Abstract

This unit describes the techniques involved in the hamster model of leptospirosis. Hamsters are exquisitely susceptible to infection with pathogenic Leptospira species. The LD(50) of virulent Leptospiral strains by intraperitoneal inoculation of 3- to 4-week-old hamsters is as low as a single organism. The pathogenesis of severe leptospirosis in the hamster is a model of accidental infections observed in nature in many mammals, including humans. Animal husbandry issues and the reproducibility of the hamster model make it the animal model of choice for Leptospiral vaccine and antibiotic treatment studies.

Entities: Species

Mesh：

Year: 2006 PMID： 18770576 PMCID： PMC2667198 DOI： 10.1002/9780471729259.mc12e02s02

Source DB: PubMed Journal: Curr Protoc Microbiol

17 in total

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Journal: Br J Exp Pathol Date: 1957-02

2. Virulence of Leptospira pomona in hamsters and cattle.

Authors: L C FERGUSON; A H HAMDY
Journal: Am J Vet Res Date: 1957-01 Impact factor: 1.156

3. Leptospiral immunoglobulin-like proteins elicit protective immunity.

Authors: Nobuo Koizumi; Haruo Watanabe
Journal: Vaccine Date: 2004-03-29 Impact factor: 3.641

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Authors: S Faine
Journal: J Hyg (Lond) Date: 1962-12

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Journal: Health Lab Sci Date: 1976-04

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Journal: Am Ind Hyg Assoc J Date: 1987-03

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Authors: C A Bolin; D P Alt
Journal: Am J Vet Res Date: 2001-07 Impact factor: 1.156

8. Leptospiral outer membrane proteins OmpL1 and LipL41 exhibit synergistic immunoprotection.

Authors: D A Haake; M K Mazel; A M McCoy; F Milward; G Chao; J Matsunaga; E A Wagar
Journal: Infect Immun Date: 1999-12 Impact factor: 3.441

9. Quantitative PCR assay to evaluate ampicillin, ofloxacin, and doxycycline for treatment of experimental leptospirosis.

Authors: Johann Truccolo; Françoise Charavay; Fabrice Merien; Philippe Perolat
Journal: Antimicrob Agents Chemother Date: 2002-03 Impact factor: 5.191

10. Experimental Leptospira pomona infection in the Mongolian gerbil (Meriones unguiculatus).

Authors: C LEWIS; J E GRAY
Journal: J Infect Dis Date: 1961 Sep-Oct Impact factor: 5.226

37 in total

Review 1. Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses.

Authors: Karen V Evangelista; Jenifer Coburn
Journal: Future Microbiol Date: 2010-09 Impact factor: 3.165

2. Infectivity and virulence of leptospiral strains of serogroup Sejroe other than Hardjo on experimentally infected hamsters.

Authors: Cristina Barbosa; Gabriel Martins; Walter Lilenbaum
Journal: Braz J Microbiol Date: 2019-07-29 Impact factor: 2.476

3. Serologic and molecular studies of Leptospira and leptospirosis among rats in the Philippines.

Authors: Sharon Y A M Villanueva; Hirokazu Ezoe; Rubelia A Baterna; Yasutake Yanagihara; Maki Muto; Nobuo Koizumi; Takashi Fukui; Yoshihiro Okamoto; Toshiyuki Masuzawa; Lolita L Cavinta; Nina G Gloriani; Shin-ichi Yoshida
Journal: Am J Trop Med Hyg Date: 2010-05 Impact factor: 2.345

4. High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection.

Authors: Kristel Lourdault; James Matsunaga; Karen V Evangelista; David A Haake
Journal: J Vis Exp Date: 2017-12-18 Impact factor: 1.355

5. Positive regulation of Leptospira interrogans kdp expression by KdpE as Demonstrated with a novel β-galactosidase reporter in Leptospira biflexa.

Authors: James Matsunaga; Mariana L Coutinho
Journal: Appl Environ Microbiol Date: 2012-06-08 Impact factor: 4.792

6. Gene expression profiles of immune mediators and histopathological findings in animal models of leptospirosis: comparison between susceptible hamsters and resistant mice.

Authors: Mariko Matsui; Vincent Rouleau; Lilian Bruyère-Ostells; Cyrille Goarant
Journal: Infect Immun Date: 2011-08-15 Impact factor: 3.441

7. Transbronchial Invasion and Proliferation of Leptospira interrogans in Lung without Inflammatory Cell Infiltration in a Hamster Model.

Authors: Yasuhiko Nikaido; Midori Ogawa; Kazumasa Fukuda; Mitsuru Yokoyama; Takaaki Kanemaru; Toshiyuki Nakayama; Mitsumasa Saito
Journal: Infect Immun Date: 2019-11-18 Impact factor: 3.441

8. Duplex real-time reverse transcriptase PCR to determine cytokine mRNA expression in a hamster model of New World cutaneous leishmaniasis.

Authors: Claudia M Espitia; Weiguo Zhao; Omar Saldarriaga; Yaneth Osorio; Lisa M Harrison; Michael Cappello; Bruno L Travi; Peter C Melby
Journal: BMC Immunol Date: 2010-06-22 Impact factor: 3.615

9. Real-Time PCR Reveals Rapid Dissemination of Leptospira interrogans after Intraperitoneal and Conjunctival Inoculation of Hamsters.

Authors: Elsio A Wunder; Claudio P Figueira; Gisele R Santos; Kristel Lourdault; Michael A Matthias; Joseph M Vinetz; Eduardo Ramos; David A Haake; Mathieu Picardeau; Mitermayer G Dos Reis; Albert I Ko
Journal: Infect Immun Date: 2016-06-23 Impact factor: 3.441

10. Differential cytokine gene expression according to outcome in a hamster model of leptospirosis.

Authors: Frédérique Vernel-Pauillac; Cyrille Goarant
Journal: PLoS Negl Trop Dis Date: 2010-01-12