Literature DB >> 18770534

Lymphocytic choriomeningitis virus (LCMV): propagation, quantitation, and storage.

Raymond M Welsh1, Mina O Seedhom.   

Abstract

Lymphocytic choriomeningitis virus (LCMV) is an enveloped, ambisense RNA virus and the prototypic virus of the arenavirus group. It can cause viral meningitis and other ailments in humans, but its natural host is the mouse. The LCMV/mouse model has been useful for examining mechanisms of viral persistence and the basic concepts of virus-induced immunity and immunopathology. This unit discusses strain differences and biosafety containment issues for LCMV. Recommendations are made for techniques for propagating LCMV to high titers to quantify it by plaque assay and PCR techniques and to preserve its infectivity by appropriate storage.

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Year:  2008        PMID： 18770534      PMCID： PMC3220596          DOI： 10.1002/9780471729259.mc15a01s8

Source DB:  PubMed          Journal:  Curr Protoc Microbiol


  10 in total

1.  Viral persistence in vivo through selection of neutralizing antibody-escape variants.

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Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

Review 2.  Reverse genetics of arenaviruses.

Authors:  K J Lee; J C de la Torre
Journal:  Curr Top Microbiol Immunol       Date:  2002       Impact factor: 4.291

3.  Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet.

Authors:  Andrew T Miller; Heather M Wilcox; Zhongbin Lai; Leslie J Berg
Journal:  Immunity       Date:  2004-07       Impact factor: 31.745

4.  CD1d1-dependent control of the magnitude of an acute antiviral immune response.

Authors:  Tonya J Roberts; Yinling Lin; Philip M Spence; Luc Van Kaer; Randy R Brutkiewicz
Journal:  J Immunol       Date:  2004-03-15       Impact factor: 5.422

5.  Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells.

Authors:  D Moskophidis; F Lechner; H Pircher; R M Zinkernagel
Journal:  Nature       Date:  1993-04-22       Impact factor: 49.962

6.  Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus.

Authors:  W Cao; M D Henry; P Borrow; H Yamada; J H Elder; E V Ravkov; S T Nichol; R W Compans; K P Campbell; M B Oldstone
Journal:  Science       Date:  1998-12-11       Impact factor: 47.728

7.  Virus-induced immunosuppression: kinetic analysis of the selection of a mutation associated with viral persistence.

Authors:  C F Evans; P Borrow; J C de la Torre; M B Oldstone
Journal:  J Virol       Date:  1994-11       Impact factor: 5.103

8.  CTL escape viral variants. I. Generation and molecular characterization.

Authors:  H Lewicki; A Tishon; P Borrow; C F Evans; J E Gairin; K M Hahn; D A Jewell; I A Wilson; M B Oldstone
Journal:  Virology       Date:  1995-06-20       Impact factor: 3.616

9.  Viral immune evasion due to persistence of activated T cells without effector function.

Authors:  A J Zajac; J N Blattman; K Murali-Krishna; D J Sourdive; M Suresh; J D Altman; R Ahmed
Journal:  J Exp Med       Date:  1998-12-21       Impact factor: 14.307

10.  Inhibition of immunologic injury of cultured cells infected with lymphocytic choriomeningitis virus: role of defective interfering virus in regulating viral antigenic expression.

Authors:  R M Welsh; M B Oldstone
Journal:  J Exp Med       Date:  1977-06-01       Impact factor: 14.307
  10 in total
  44 in total

1.  Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity.

Authors:  Philipp A Lang; Karl S Lang; Haifeng C Xu; Melanie Grusdat; Ian A Parish; Mike Recher; Alisha R Elford; Salim Dhanji; Namir Shaabani; Charles W Tran; Dilan Dissanayake; Ramtin Rahbar; Magar Ghazarian; Anne Brüstle; Jason Fine; Peter Chen; Casey T Weaver; Christoph Klose; Andreas Diefenbach; Dieter Häussinger; James R Carlyle; Susan M Kaech; Tak W Mak; Pamela S Ohashi
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-13       Impact factor: 11.205

2.  Evaluation of non-reciprocal heterologous immunity between unrelated viruses.

Authors:  Jenny W Che; Liisa K Selin; Raymond M Welsh
Journal:  Virology       Date:  2015-03-31       Impact factor: 3.616

3.  IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis.

Authors:  Yuejin Liang; Panpan Yi; Denley Ming Kee Yuan; Zuliang Jie; Zakari Kwota; Lynn Soong; Yingzi Cong; Jiaren Sun
Journal:  Cell Mol Immunol       Date:  2018-02-05       Impact factor: 11.530

4.  Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening.

Authors:  Jessica Y Rathbun; Magali E Droniou; Robert Damoiseaux; Kevin G Haworth; Jill E Henley; Colin M Exline; Hyeryun Choe; Paula M Cannon
Journal:  J Virol       Date:  2015-06-03       Impact factor: 5.103

5.  Long noncoding RNA Malat1 is not essential for T cell development and response to LCMV infection.

Authors:  Yingpeng Yao; Wenhui Guo; Jingjing Chen; Pingting Guo; Guotao Yu; Juanjuan Liu; Fang Wang; Jingjing Liu; Menghao You; Tianyan Zhao; Youmin Kang; Xi Ma; Shuyang Yu
Journal:  RNA Biol       Date:  2018-12-04       Impact factor: 4.652

6.  IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions.

Authors:  Heather D Marshall; Amanda L Prince; Leslie J Berg; Raymond M Welsh
Journal:  J Immunol       Date:  2010-06-30       Impact factor: 5.422

7.  Regulation of tissue-dependent differences in CD8+ T cell apoptosis during viral infection.

Authors:  Varun N Kapoor; Hyun Mu Shin; Ok Hyun Cho; Leslie J Berg; Joonsoo Kang; Raymond M Welsh
Journal:  J Virol       Date:  2014-06-18       Impact factor: 5.103

8.  PD-L1 Checkpoint Inhibition Narrows the Antigen-Specific T Cell Receptor Repertoire in Chronic Lymphocytic Choriomeningitis Virus Infection.

Authors:  S Klein; D Ghersi; M P Manns; I Prinz; M Cornberg; A R M Kraft
Journal:  J Virol       Date:  2020-08-31       Impact factor: 5.103

9.  Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.

Authors:  Anfei Huang; Prashant V Shinde; Jun Huang; Tina Senff; Haifeng C Xu; Cassandra Margotta; Dieter Häussinger; Thomas E Willnow; Jinping Zhang; Aleksandra A Pandyra; Jörg Timm; Sascha Weggen; Karl S Lang; Philipp A Lang
Journal:  JCI Insight       Date:  2019-09-05

10.  The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection.

Authors:  Howell F Moffett; Adam N R Cartwright; Hye-Jung Kim; Jernej Godec; Jason Pyrdol; Tarmo Äijö; Gustavo J Martinez; Anjana Rao; Jun Lu; Todd R Golub; Harvey Cantor; Arlene H Sharpe; Carl D Novina; Kai W Wucherpfennig
Journal:  Nat Immunol       Date:  2017-05-22       Impact factor: 25.606
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