| Literature DB >> 18769865 |
Sabina Resic-Lindehammer1, K Larsson, E Ortqvist, A Carlsson, E Cederwall, C M Cilio, S-A Ivarsson, B A Jönsson, H E Larsson, K Lynch, J Neiderud, A Nilsson, S Sjöblad, A Lernmark, M Aili, L E Bååth, E Carlsson, H Edenwall, G Forsander, B W Granstro, I Gustavsson, R Hanås, L Hellenberg, H Hellgren, E Holmberg, H Hörnell, Sten-A Ivarsson, C Johansson, G Jonsell, K Kockum, B Lindblad, A Lindh, J Ludvigsson, U Myrdal, J Neiderud, K Segnestam, S Sjöblad, L Skogsberg, L Strömberg, U Ståhle, B Thalme, K Tullus, T Tuvemo, M Wallensteen, O Westphal, J Aman.
Abstract
The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.Entities:
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Year: 2008 PMID： 18769865 DOI： 10.1007/s00592-008-0048-5
Source DB: PubMed Journal: Acta Diabetol ISSN： 0940-5429 Impact factor: 4.280