Ting Fan Leung1, Gary W K Wong. 1. Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China.
Abstract
PURPOSE OF REVIEW: There is wide variation in the global epidemiology of allergic diseases, and the prevalence rates of asthma and allergy differ significantly among different Asian populations. The diversity of environment and ethnic background in Asia provide excellent opportunities for research into the environmental and genetic determinants of asthma and allergies. This review summarizes important lessons learnt from research findings from Asia on asthma and allergy. RECENT FINDINGS: Recent epidemiologic studies revealed wide variation and increasing prevalence of asthma and allergy in many Asian countries. Comparative studies of population of the same ethnic background living in different environments revealed important environmental risk factors for asthma. Ambient air pollution plays an important role in the morbidity of patients with asthma but does not seem to affect the prevalence of asthma. There were many genetic association studies for allergic diseases from Asia. These studies identified novel gene targets, such as CD40, DCNP1 and PTGS2, for asthma and allergen sensitization whereas many others replicated the genetic associations on known candidate genes for asthma and atopic dermatitis. SUMMARY: Epidemiologic and genetic researches in Asia advance our knowledge on the disease prevalence, healthcare burden and pathogenesis of asthma and allergy.
PURPOSE OF REVIEW: There is wide variation in the global epidemiology of allergic diseases, and the prevalence rates of asthma and allergy differ significantly among different Asian populations. The diversity of environment and ethnic background in Asia provide excellent opportunities for research into the environmental and genetic determinants of asthma and allergies. This review summarizes important lessons learnt from research findings from Asia on asthma and allergy. RECENT FINDINGS: Recent epidemiologic studies revealed wide variation and increasing prevalence of asthma and allergy in many Asian countries. Comparative studies of population of the same ethnic background living in different environments revealed important environmental risk factors for asthma. Ambient air pollution plays an important role in the morbidity of patients with asthma but does not seem to affect the prevalence of asthma. There were many genetic association studies for allergic diseases from Asia. These studies identified novel gene targets, such as CD40, DCNP1 and PTGS2, for asthma and allergen sensitization whereas many others replicated the genetic associations on known candidate genes for asthma and atopic dermatitis. SUMMARY: Epidemiologic and genetic researches in Asia advance our knowledge on the disease prevalence, healthcare burden and pathogenesis of asthma and allergy.
Authors: Shu E Soh; Samuel Shang Ming Lee; Sarah Wenli Hoon; Mae Yun Tan; Anne Goh; Bee Wah Lee; Lynette Pei-Chi Shek; Oon Hoe Teoh; Kenneth Kwek; Seang Mei Saw; Keith Godfrey; Yap Seng Chong; Peter Gluckman; Hugo Ps van Bever Journal: Asia Pac Allergy Date: 2012-04-23