Literature DB >> 18768524

Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer.

Thorvardur R Halfdanarson1, Liang Wang, William R Bamlet, Mariza de Andrade, Robert R McWilliams, Julie M Cunningham, Gloria M Petersen.   

Abstract

Pancreatic cancer is a highly lethal malignancy, and the majority of patients succumb to the disease within 2 years. We evaluated the role of variants of mitochondrial DNA and mitochondrial haplogroups in predicting prognosis of patients with pancreatic cancer. A total of 24 mitochondrial single nucleotide polymorphisms were genotyped in 990 patients with pancreatic cancer. After adjusting for covariates and multiple comparisons, no association between any of the mitochondrial single nucleotide polymorphisms or haplogroups and survival was observed.

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Year:  2008        PMID： 18768524      PMCID： PMC2674364          DOI： 10.1158/1055-9965.EPI-08-0460

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  7 in total

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Authors:  A Chatterjee; E Mambo; D Sidransky
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Journal:  Am J Clin Pathol       Date:  2006-10       Impact factor: 2.493

4.  A common mitochondrial DNA variant is associated with insulin resistance in adult life.

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5.  Cancer statistics, 2007.

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6.  The 16189 variant of mitochondrial DNA occurs more frequently in C282Y homozygotes with haemochromatosis than those without iron loading.

Authors:  K J Livesey; V L C Wimhurst; K Carter; M Worwood; E Cadet; J Rochette; A G Roberts; J J Pointon; A T Merryweather-Clarke; M L Bassett; A-M Jouanolle; A Mosser; V David; J Poulton; K J H Robson
Journal:  J Med Genet       Date:  2004-01       Impact factor: 6.318

7.  Mitochondrial genetic polymorphisms and pancreatic cancer risk.

Authors:  Liang Wang; William R Bamlet; Mariza de Andrade; Lisa A Boardman; Julie M Cunningham; Stephen N Thibodeau; Gloria M Petersen
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2007-07       Impact factor: 4.254
  7 in total
  7 in total

1.  A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival.

Authors:  Jason A Willis; Sara H Olson; Irene Orlow; Semanti Mukherjee; Robert R McWilliams; Robert C Kurtz; Robert J Klein
Journal:  Clin Cancer Res       Date:  2012-06-04       Impact factor: 12.531

Review 2.  Mitochondrial determinants of cancer health disparities.

Authors:  Aaheli Roy Choudhury; Keshav K Singh
Journal:  Semin Cancer Biol       Date:  2017-05-06       Impact factor: 15.707

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4.  Risk factors for pancreatic neuroendocrine tumors: a clinic-based case-control study.

Authors:  Thorvardur R Halfdanarson; William R Bamlet; Robert R McWilliams; Timothy J Hobday; Patrick A Burch; Kari G Rabe; Gloria M Petersen
Journal:  Pancreas       Date:  2014-11       Impact factor: 3.327

Review 5.  Current status of molecular markers for early detection of sporadic pancreatic cancer.

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Authors:  Ernest T Lam; Paige M Bracci; Elizabeth A Holly; Catherine Chu; Annie Poon; Eunice Wan; Krystal White; Pui-Yan Kwok; Ludmila Pawlikowska; Gregory J Tranah
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Review 7.  An overview of genetic polymorphisms and pancreatic cancer risk in molecular epidemiologic studies.

Authors:  Yingsong Lin; Kiyoko Yagyu; Naoto Egawa; Makoto Ueno; Mitsuru Mori; Haruhisa Nakao; Hiroshi Ishii; Kozue Nakamura; Kenji Wakai; Satoyo Hosono; Akiko Tamakoshi; Shogo Kikuchi
Journal:  J Epidemiol       Date:  2010-11-06       Impact factor: 3.211
  7 in total

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