Literature DB >> 1876837

Design and synthesis of a mimetic from an antibody complementarity-determining region.

H U Saragovi1, D Fitzpatrick, A Raktabutr, H Nakanishi, M Kahn, M I Greene.   

Abstract

A technique for producing non-peptide compounds (mimetics) of designed specificities was developed that permitted the synthesis of a conformationally restricted molecule that mimicked the binding and functional properties of monoclonal antibody (MAb) 87.92.6, which recognizes the reovirus type 3 cellular receptor. Binding of either MAb 87.92.6, peptide analogs, or 87.1-mimetic to the cellular receptor inhibited cellular proliferation. The mimetic was a synthetic beta-loop structure that mimics the second complementarity-determining region of the MAb. These studies may lead to strategies for the synthetic design of antibody complementarity regions, ligands, and other pharmacologically active agents that are water soluble, resistant to proteolysis, and nonimmunogenic.

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Year:  1991        PMID： 1876837     DOI： 10.1126/science.1876837

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  27 in total

1.  Inhibition of the HIV-1 and HIV-2 proteases by a monoclonal antibody.

Authors:  J Lescar; J Brynda; P Rezacova; R Stouracova; M M Riottot; V Chitarra; M Fabry; M Horejsi; J Sedlacek; G A Bentley
Journal:  Protein Sci       Date:  1999-12       Impact factor: 6.725

2.  A family of concanavalin A-binding peptides from a hexapeptide epitope library.

Authors:  J K Scott; D Loganathan; R B Easley; X Gong; I J Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

3.  Molecular-dynamics investigation of molecular flexibility in ligand binding.

Authors:  B Mao
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

Review 4.  Antibody-enabled small-molecule drug discovery.

Authors:  Alastair D G Lawson
Journal:  Nat Rev Drug Discov       Date:  2012-06-29       Impact factor: 84.694

5.  Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death.

Authors:  Sung-Wuk Jang; Masashi Okada; Iqbal Sayeed; Ge Xiao; Donald Stein; Peng Jin; Keqiang Ye
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-02       Impact factor: 11.205

6.  Modelling of peptide and protein structures.

Authors:  S Fraga; J M Parker
Journal:  Amino Acids       Date:  1994-06       Impact factor: 3.520

Review 7.  Antibody imaging in the evaluation of cardiovascular diseases.

Authors:  B A Khaw; J Narula
Journal:  J Nucl Cardiol       Date:  1994 Sep-Oct       Impact factor: 5.952

8.  Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1.

Authors:  J D Chappell; V L Gunn; J D Wetzel; G S Baer; T S Dermody
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

9.  Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes.

Authors:  S Chen; R A Chrusciel; H Nakanishi; A Raktabutr; M E Johnson; A Sato; D Weiner; J Hoxie; H U Saragovi; M I Greene
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-01       Impact factor: 11.205

10.  Chemicals possessing a neurotrophin-like activity on dopaminergic neurons in primary culture.

Authors:  Fanny Schmidt; Pierre Champy; Blandine Séon-Méniel; Xavier Franck; Rita Raisman-Vozari; Bruno Figadère
Journal:  PLoS One       Date:  2009-07-10       Impact factor: 3.240
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