Literature DB >> 18768316

Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7.

Weihong Zheng1, Alexei Degterev, Emily Hsu, Junying Yuan, Chengye Yuan.   

Abstract

Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modifications and the structure-activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18768316     DOI： 10.1016/j.bmcl.2008.08.058

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  21 in total

Review 1.  Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

Authors:  Tom Vanden Berghe; Andreas Linkermann; Sandrine Jouan-Lanhouet; Henning Walczak; Peter Vandenabeele
Journal:  Nat Rev Mol Cell Biol       Date:  2014-02       Impact factor: 94.444

2.  Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization.

Authors:  Chendong Pan; Kalpita Banerjee; Guillermo L Lehmann; Dena Almeida; Katherine A Hajjar; Ignacio Benedicto; Zhichun Jiang; Roxana A Radu; David H Thompson; Enrique Rodriguez-Boulan; Marcelo M Nociari
Journal:  Proc Natl Acad Sci U S A       Date:  2021-11-23       Impact factor: 11.205

3.  4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer.

Authors:  Jakub Hanus; Alexander Kolkin; Julia Chimienti; Sara Botsay; Shusheng Wang
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-08       Impact factor: 4.799

Review 4.  Generation of small molecules to interfere with regulated necrosis.

Authors:  Alexei Degterev; Andreas Linkermann
Journal:  Cell Mol Life Sci       Date:  2016-04-05       Impact factor: 9.261

5.  3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.

Authors:  Eumorphia G Konstantakou; Gerassimos E Voutsinas; Athanassios D Velentzas; Aggeliki-Stefania Basogianni; Efthimios Paronis; Evangelos Balafas; Nikolaos Kostomitsopoulos; Konstantinos N Syrigos; Ema Anastasiadou; Dimitrios J Stravopodis
Journal:  Mol Cancer       Date:  2015-07-22       Impact factor: 27.401

6.  Induction of necrotic cell death by oxidative stress in retinal pigment epithelial cells.

Authors:  J Hanus; H Zhang; Z Wang; Q Liu; Q Zhou; S Wang
Journal:  Cell Death Dis       Date:  2013-12-12       Impact factor: 8.469

7.  The effect and underlying mechanism of Timosaponin B-II on RGC-5 necroptosis induced by hydrogen peroxide.

Authors:  San-Hong Jiang; Lei Shang; Li-Xiang Xue; Wei Ding; Shuang Chen; Ruo-Fei Ma; Ju-Fang Huang; Kun Xiong
Journal:  BMC Complement Altern Med       Date:  2014-12-02       Impact factor: 3.659

8.  Necroptosis in Niemann-Pick disease, type C1: a potential therapeutic target.

Authors:  A Cougnoux; C Cluzeau; S Mitra; R Li; I Williams; K Burkert; X Xu; C A Wassif; W Zheng; F D Porter
Journal:  Cell Death Dis       Date:  2016-03-17       Impact factor: 8.469

9.  Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus.

Authors:  Zhi-Wei Lai; Rebecca Borsuk; Ashwini Shadakshari; Jianghong Yu; Maha Dawood; Ricardo Garcia; Lisa Francis; Hajra Tily; Adam Bartos; Stephen V Faraone; Paul Phillips; Andras Perl
Journal:  J Immunol       Date:  2013-08-02       Impact factor: 5.422

10.  Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.

Authors:  Boxiao Ding; Anita Parmigiani; Ajit S Divakaruni; Kellie Archer; Anne N Murphy; Andrei V Budanov
Journal:  Sci Rep       Date:  2016-03-02       Impact factor: 4.379
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.