OBJECTIVE: The purpose of this study was to determine whether, in a group of children with type 1 diabetes using insulin pump, a prebedtime snack with a relatively high fat content provides greater protection from nocturnal hypoglycemia than a snack containing the same amount of carbohydrate and protein but a lower fat content. RESEARCH DESIGN AND METHODS: Ten subjects, aged 6 to <18 yr, in a trial evaluating the Abbott Navigator glucose sensor, agreed to this ancillary study. On 12 or more separate nights, each subject was randomized by a Web site to a carbohydrate-low-fat (30 g CHO, 2.5 g protein, and 1.3 g fat; 138 kcal) snack or a carbohydrate-high-fat (30 g CHO, 2 g protein, and 20 g fat; 320 kcal) snack. Subjects used their usual evening snack algorithm to determine the size (in 15-g carbohydrate increments) and insulin dosage. RESULTS: Average glucose on 128 valid study nights before snack was similar in both groups. The proportion of nights with hypoglycemia (a sensor or meter glucose value <or=70 mg/dL) was similar in both groups (19% high fat vs. 20% low fat), as was the proportion of nights with hyperglycemia (a glucose >or=200 mg/dL and at least 50 mg/dL above baseline, 35% high fat vs. 30% low fat). CONCLUSIONS: There were no statistical differences between the high- and low-fat snacks on the frequency of hyperglycemia or hypoglycemia. This study highlights the feasibility of web-based research in patients' home environment.
RCT Entities:
OBJECTIVE: The purpose of this study was to determine whether, in a group of children with type 1 diabetes using insulin pump, a prebedtime snack with a relatively high fat content provides greater protection from nocturnal hypoglycemia than a snack containing the same amount of carbohydrate and protein but a lower fat content. RESEARCH DESIGN AND METHODS: Ten subjects, aged 6 to <18 yr, in a trial evaluating the Abbott Navigator glucose sensor, agreed to this ancillary study. On 12 or more separate nights, each subject was randomized by a Web site to a carbohydrate-low-fat (30 g CHO, 2.5 g protein, and 1.3 g fat; 138 kcal) snack or a carbohydrate-high-fat (30 g CHO, 2 g protein, and 20 g fat; 320 kcal) snack. Subjects used their usual evening snack algorithm to determine the size (in 15-g carbohydrate increments) and insulin dosage. RESULTS: Average glucose on 128 valid study nights before snack was similar in both groups. The proportion of nights with hypoglycemia (a sensor or meter glucose value <or=70 mg/dL) was similar in both groups (19% high fat vs. 20% low fat), as was the proportion of nights with hyperglycemia (a glucose >or=200 mg/dL and at least 50 mg/dL above baseline, 35% high fat vs. 30% low fat). CONCLUSIONS: There were no statistical differences between the high- and low-fat snacks on the frequency of hyperglycemia or hypoglycemia. This study highlights the feasibility of web-based research in patients' home environment.
Authors: T Danne; H B Mortensen; P Hougaard; H Lynggaard; H J Aanstoot; F Chiarelli; D Daneman; H Dorchy; P Garandeau; S A Greene; H Hoey; R W Holl; E A Kaprio; M Kocova; P Martul; N Matsuura; K J Robertson; E J Schoenle; O Søvik; P G Swift; R M Tsou; M Vanelli; J Aman Journal: Diabetes Care Date: 2001-08 Impact factor: 19.112
Authors: Arleta Rewers; H Peter Chase; Todd Mackenzie; Philip Walravens; Mark Roback; Marian Rewers; Richard F Hamman; Georgeanna Klingensmith Journal: JAMA Date: 2002-05-15 Impact factor: 56.272
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Authors: T Danne; H W de Valk; T Kracht; K Walte; R Geldmacher; L Sölter; W von dem Berge; Z K Welsh; J R Bugler; K Lange; O Kordonouri Journal: Diabetologia Date: 2009-06-13 Impact factor: 10.122
Authors: Megan Paterson; Kirstine J Bell; Susan M O'Connell; Carmel E Smart; Amir Shafat; Bruce King Journal: Curr Diab Rep Date: 2015-09 Impact factor: 4.810