Literature DB >> 18767856

Catalytic asymmetric conjugate addition of grignard reagents to alpha,beta-unsaturated sulfones.

Pieter H Bos1, Adriaan J Minnaard, Ben L Feringa.   

Abstract

A highly efficient method is reported for the asymmetric conjugate addition of Grignard reagents to alpha,beta-unsaturated 2-pyridylsulfones. Using a Cu/TolBinap complex, excellent enantioselectivities and high yields are obtained for a wide variety of aliphatic substrates.

Entities:  

Year:  2008        PMID： 18767856     DOI： 10.1021/ol801566n

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Catalytic enantioselective conjugate additions with α,β-unsaturated sulfones.

Authors:  Hongming Li; Jun Song; Li Deng
Journal:  Tetrahedron       Date:  2009-04-18       Impact factor: 2.457

2.  Main group multiple C-H/N-H bond activation of a diamine and isolation of a molecular dilithium zincate hydride: experimental and DFT evidence for alkali metal-zinc synergistic effects.

Authors:  Ross Campbell; Daniel Cannon; Pablo García-Álvarez; Alan R Kennedy; Robert E Mulvey; Stuart D Robertson; Jörg Sassmannshausen; Tell Tuttle
Journal:  J Am Chem Soc       Date:  2011-08-04       Impact factor: 15.419

3.  Davis-Beirut reaction: route to thiazolo-, thiazino-, and thiazepino-2H-indazoles.

Authors:  Kelli M Farber; Makhluf J Haddadin; Mark J Kurth
Journal:  J Org Chem       Date:  2014-07-23       Impact factor: 4.354
  3 in total

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