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Literature DB >> 18767247

Leukemia/lymphoma-associated gene fusions in normal individuals.

Abstract

Hematopoietic neoplasias are characterized by recurrent chromosomal aberrations that result in the formation of gene fusions and the subsequent expression of chimeric proteins with unique properties. However, in recent years, different lymphoma/leukemia-associated rearrangements, such as BCR/ABL, IGH/BCL2, ETV6/RUNX1 and MLL duplications, have been detected in healthy individuals. The presence of these rearrangements indicates that such translocations can be generated in normal hematopoietic cells without apparent oncogenic consequences. This article reviews and discusses the data available in the literature.

Entities: Disease Gene

Mesh：

Year: 2008 PMID： 18767247 DOI： 10.4238/vol7-3gmr486

Source DB: PubMed Journal: Genet Mol Res ISSN： 1676-5680

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Cited

5 in total

1. Methylation of the nonhomologous end joining repair pathway genes does not explain the increase of translocations with aging.

Authors: Idoia Martín-Guerrero; Elena de Prado; Elixabet Lopez-Lopez; Maite Ardanaz; Juan Carlos Vitoria; Luis A Parada; Cristina García-Orad; Africa García-Orad
Journal: Age (Dordr) Date: 2014-11-16

Review 5. Hypothesis: Artifacts, Including Spurious Chimeric RNAs with a Short Homologous Sequence, Caused by Consecutive Reverse Transcriptions and Endogenous Random Primers.

Authors: Zhiyu Peng; Chengfu Yuan; Lucas Zellmer; Siqi Liu; Ningzhi Xu; D Joshua Liao
Journal: J Cancer Date: 2015-05-01 Impact factor: 4.207

5 in total

Leukemia/lymphoma-associated gene fusions in normal individuals.

1. Methylation of the nonhomologous end joining repair pathway genes does not explain the increase of translocations with aging.

Review 2. How animal models of leukaemias have already benefited patients.

3. New experimental and theoretical investigations of hematopoietic stem cells and chronic myeloid leukemia.

4. Dissect: detection and characterization of novel structural alterations in transcribed sequences.

Review 5. Hypothesis: Artifacts, Including Spurious Chimeric RNAs with a Short Homologous Sequence, Caused by Consecutive Reverse Transcriptions and Endogenous Random Primers.