BACKGROUND: This study prospectively assessed 2-[F18]-fluoro-2-deoxy-D-glucose-positron emission tomography (18F-FDG-PET)/CT (PET/CT) in oral squamous cell carcinoma. METHODS: Twenty-three patients completed preoperative TNM staging (CT, MR, whole-body fusion imaging PET/CT). In patients who underwent surgical therapy (19 of 23), TNM staging based on PET/CT scan was compared with pTNM. RESULTS: PET/CT correctly staged 16 of 19 primary tumors (accuracy 84.2%, sensitivity 84.2%, positive predictive value 100%) and correctly ruled out bone invasion in 3 patients with false-positive results according to CT and/or MR. PET/CT incorrectly identified neck involvement in 5 of 15 patients (3 false positives, 2 false negatives) who underwent neck dissection (accuracy 66.7%, specificity 76.9%, negative predictive value 83.3%). False-negative cases showed a nodal size not exceeding 10 mm. One patient with a bronchial synchronous primary tumor was identified. CONCLUSION: PET/CT scan showed good accuracy in determining the extension and/or depth of invasion of the primary tumor. Nevertheless, PET/CT was not accurate to rule out nodal metastases. (c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.
BACKGROUND: This study prospectively assessed 2-[F18]-fluoro-2-deoxy-D-glucose-positron emission tomography (18F-FDG-PET)/CT (PET/CT) in oral squamous cell carcinoma. METHODS: Twenty-three patients completed preoperative TNM staging (CT, MR, whole-body fusion imaging PET/CT). In patients who underwent surgical therapy (19 of 23), TNM staging based on PET/CT scan was compared with pTNM. RESULTS: PET/CT correctly staged 16 of 19 primary tumors (accuracy 84.2%, sensitivity 84.2%, positive predictive value 100%) and correctly ruled out bone invasion in 3 patients with false-positive results according to CT and/or MR. PET/CT incorrectly identified neck involvement in 5 of 15 patients (3 false positives, 2 false negatives) who underwent neck dissection (accuracy 66.7%, specificity 76.9%, negative predictive value 83.3%). False-negative cases showed a nodal size not exceeding 10 mm. One patient with a bronchial synchronous primary tumor was identified. CONCLUSION: PET/CT scan showed good accuracy in determining the extension and/or depth of invasion of the primary tumor. Nevertheless, PET/CT was not accurate to rule out nodal metastases. (c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.
Authors: Angelina Cistaro; Francesco Saglio; Sebastian Asaftei; Piercarlo Fania; Massimo Berger; Franca Fagioli Journal: Radiol Case Rep Date: 2015-11-06
Authors: Till A Heusner; Steffen Hahn; Monia E Hamami; Svenja Kögel; Michael Forsting; Andreas Bockisch; Gerald Antoch; Alexander R Stahl Journal: Eur J Nucl Med Mol Imaging Date: 2009-03-21 Impact factor: 9.236
Authors: Jessica Clark; Caroline C Jeffery; Han Zhang; Tim Cooper; Daniel A O'Connell; Jeffrey Harris; Hadi Seikaly; Vincent L Biron Journal: J Otolaryngol Head Neck Surg Date: 2015-09-15