BACKGROUND: Data regarding the use of corticosteroids for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis are conflicting. The aim of this meta-analysis was to compare corticosteroids with placebo for prevention of post-ERCP pancreatitis. METHODS: Multiple databases including MEDLINE, EMBASE, Cochrane controlled trials register, the Cochrane Library, Science Citation Index, Google Scholar and Google updated to June 2007 were searched to retrieve the relevant randomized controlled trials. Primary outcome measure was post-ERCP pancreatitis. RESULTS: Six randomized controlled trials involving 2,448 patients were identified. The analysis showed that corticosteroids did not prevent post-ERCP pancreatitis (OR 1.13: 95% CI [0.88, 1.46]). Subsequent sensitivity and subgroup analyses according to different criteria all confirmed these results. CONCLUSIONS: Based on available evidence, prophylactic corticosteroids do not reduce the incidence of post-ERCP pancreatitis. Copyright 2008 S. Karger AG, Basel.
BACKGROUND: Data regarding the use of corticosteroids for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis are conflicting. The aim of this meta-analysis was to compare corticosteroids with placebo for prevention of post-ERCP pancreatitis. METHODS: Multiple databases including MEDLINE, EMBASE, Cochrane controlled trials register, the Cochrane Library, Science Citation Index, Google Scholar and Google updated to June 2007 were searched to retrieve the relevant randomized controlled trials. Primary outcome measure was post-ERCP pancreatitis. RESULTS: Six randomized controlled trials involving 2,448 patients were identified. The analysis showed that corticosteroids did not prevent post-ERCP pancreatitis (OR 1.13: 95% CI [0.88, 1.46]). Subsequent sensitivity and subgroup analyses according to different criteria all confirmed these results. CONCLUSIONS: Based on available evidence, prophylactic corticosteroids do not reduce the incidence of post-ERCP pancreatitis. Copyright 2008 S. Karger AG, Basel.
Authors: Pezhman Alavi Nejad; Eskandar Hajiani; Jalal Hashemi; Abdol Rahim Masjedizadeh; Ali Akbar Shayesteh; Vahid Sebghatollahi Journal: Middle East J Dig Dis Date: 2013-01
Authors: Mahmud Mahamid; Abdulla Watad; Nicola L Bragazzi; Dov Wengrower; Julie Wolff; Dan Livovsky; Howard Amital; Mohammad Adawi; Eran Goldin Journal: Front Pharmacol Date: 2018-06-29 Impact factor: 5.810