| Literature DB >> 18765804 |
Hasse Walum1, Lars Westberg, Susanne Henningsson, Jenae M Neiderhiser, David Reiss, Wilmar Igl, Jody M Ganiban, Erica L Spotts, Nancy L Pedersen, Elias Eriksson, Paul Lichtenstein.
Abstract
Pair-bonding has been suggested to be a critical factor in the evolutionary development of the social brain. The brain neuropeptide arginine vasopressin (AVP) exerts an important influence on pair-bonding behavior in voles. There is a strong association between a polymorphic repeat sequence in the 5' flanking region of the gene (avpr1a) encoding one of the AVP receptor subtypes (V1aR), and proneness for monogamous behavior in males of this species. It is not yet known whether similar mechanisms are important also for human pair-bonding. Here, we report an association between one of the human AVPR1A repeat polymorphisms (RS3) and traits reflecting pair-bonding behavior in men, including partner bonding, perceived marital problems, and marital status, and show that the RS3 genotype of the males also affects marital quality as perceived by their spouses. These results suggest an association between a single gene and pair-bonding behavior in humans, and indicate that the well characterized influence of AVP on pair-bonding in voles may be of relevance also for humans.Entities:
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Year: 2008 PMID： 18765804 PMCID： PMC2533683 DOI： 10.1073/pnas.0803081105
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205