Literature DB >> 18765088

The angiotensin II type 2 receptor: what is its clinical significance?

Ivonne Hernandez Schulman1, Leopoldo Raij.   

Abstract

Angiotensin (Ang) II exerts its important physiologic functions through two distinct receptor subtypes, the type 1 (AT1) and type 2 (AT2) receptors. AT1 and AT2 receptors have demonstrated counterregulatory interactions in the cardiovascular and renal systems. The cross-talk between AT1 and AT2 receptors has been suggested to participate in regulating blood pressure, cardiovascular growth, fibrosis, and remodeling, as well as renal blood flow, growth, fibrosis, and sodium excretion. The AT1 receptor is distributed ubiquitously and abundantly in adult tissues, whereas expression of the AT2 receptor is high in the fetus but low in adult tissues. However, mounting evidence indicates that AT2 receptor cardiovascular expression increases in response to injury and AT1 receptor blocker therapy. This article reviews recent experimental and clinical data elucidating the role of the AT2 receptor in cardiovascular and renal homeostasis.

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Year:  2008        PMID： 18765088     DOI： 10.1007/s11906-008-0036-8

Source DB:  PubMed          Journal:  Curr Hypertens Rep        ISSN： 1522-6417            Impact factor:   5.369


  51 in total

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Authors:  Kathy K Griendling; Garret A FitzGerald
Journal:  Circulation       Date:  2003-10-21       Impact factor: 29.690

Review 2.  Putting the brakes on cardiac hypertrophy: exploiting the NO-cGMP counter-regulatory system.

Authors:  George W Booz
Journal:  Hypertension       Date:  2005-02-14       Impact factor: 10.190

3.  Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats.

Authors:  M Julia Brosnan; Carlene A Hamilton; Delyth Graham; Craig A Lygate; Emma Jardine; Anna F Dominiczak
Journal:  J Hypertens       Date:  2002-02       Impact factor: 4.844

4.  Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists.

Authors:  Francesco Cosentino; Carmine Savoia; Paola De Paolis; Pietro Francia; Alessandro Russo; Angelo Maffei; Vanessa Venturelli; Marzia Schiavoni; Giuseppe Lembo; Massimo Volpe
Journal:  Am J Hypertens       Date:  2005-04       Impact factor: 2.689

Review 5.  The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease.

Authors:  Giuseppe Remuzzi; Norberto Perico; Manuel Macia; Piero Ruggenenti
Journal:  Kidney Int Suppl       Date:  2005-12       Impact factor: 10.545

6.  Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor.

Authors:  H M Siragy; T Inagami; T Ichiki; R M Carey
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-25       Impact factor: 11.205

7.  Angiotensin II-induced apoptosis in rat cardiomyocyte culture: a possible role of AT1 and AT2 receptors.

Authors:  I Goldenberg; E Grossman; K A Jacobson; V Shneyvays; A Shainberg
Journal:  J Hypertens       Date:  2001-09       Impact factor: 4.844

8.  Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis.

Authors:  Satoshi Kurisu; Ryoji Ozono; Tetsuya Oshima; Masayuki Kambe; Takafumi Ishida; Hiroshi Sugino; Hideo Matsuura; Kazuaki Chayama; Yasuhiro Teranishi; Osamu Iba; Katsuya Amano; Hiroaki Matsubara
Journal:  Hypertension       Date:  2003-01       Impact factor: 10.190

9.  Left ventricle mass index and the common, functional, X-linked angiotensin II type-2 receptor gene polymorphism (-1332 G/A) in patients with systemic hypertension.

Authors:  Khaled Alfakih; Azhar Maqbool; Mohan Sivananthan; Kevin Walters; Gavin Bainbridge; John Ridgway; Anthony J Balmforth; Alistair S Hall
Journal:  Hypertension       Date:  2004-05-03       Impact factor: 10.190

10.  Overexpression of angiotensin type 2 receptor ameliorates glomerular injury in a mouse remnant kidney model.

Authors:  Naoko Hashimoto; Yohei Maeshima; Minoru Satoh; Masahiro Odawara; Hitoshi Sugiyama; Naoki Kashihara; Hiroaki Matsubara; Yasushi Yamasaki; Hirofumi Makino
Journal:  Am J Physiol Renal Physiol       Date:  2003-10-28
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  11 in total

1.  Role of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in airway reactivity and inflammation in an allergic mouse model of asthma.

Authors:  Mehaben Patel; Mangesh Kurade; Sahith Rajalingam; Riya Bhavsar; S Jamal Mustafa; Dovenia S Ponnoth
Journal:  Immunopharmacol Immunotoxicol       Date:  2019-05-07       Impact factor: 2.730

Review 2.  Role of shear stress and stretch in vascular mechanobiology.

Authors:  Deshun Lu; Ghassan S Kassab
Journal:  J R Soc Interface       Date:  2011-07-06       Impact factor: 4.118

3.  Angiotensin II type 2 receptor-coupled nitric oxide production modulates free radical availability and voltage-gated Ca2+ currents in NTS neurons.

Authors:  Gang Wang; Christal G Coleman; Michael J Glass; Ping Zhou; Qi Yu; Laibaik Park; Josef Anrather; Virginia M Pickel; Costantino Iadecola
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2012-02-29       Impact factor: 3.619

4.  Role of the angiotensin II AT2 receptor in inflammation and oxidative stress: opposing effects in lean and obese Zucker rats.

Authors:  Rifat Sabuhi; Quaisar Ali; Mohammad Asghar; Najah Riesh Hadi Al-Zamily; Tahir Hussain
Journal:  Am J Physiol Renal Physiol       Date:  2011-01-05

5.  Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells.

Authors:  John J Gildea; Xiaoli Wang; Neema Shah; Hanh Tran; Michael Spinosa; Robert Van Sciver; Midori Sasaki; Junichi Yatabe; Robert M Carey; Pedro A Jose; Robin A Felder
Journal:  Hypertension       Date:  2012-06-18       Impact factor: 10.190

6.  Role of prolylcarboxypeptidase in angiotensin II type 2 receptor-mediated bradykinin release in mouse coronary artery endothelial cells.

Authors:  Liping Zhu; Oscar A Carretero; Tang-Dong Liao; Pamela Harding; Hongwei Li; Colin Sumners; Xiao-Ping Yang
Journal:  Hypertension       Date:  2010-07-06       Impact factor: 10.190

Review 7.  Angiotensin receptors as determinants of life span.

Authors:  Paola Cassis; Sara Conti; Giuseppe Remuzzi; Ariela Benigni
Journal:  Pflugers Arch       Date:  2009-09-11       Impact factor: 3.657

8.  Attenuation of angiotensin type 2 receptor function in the rostral ventrolateral medullary pressor area of the spontaneously hypertensive rat.

Authors:  Tetsuya Kawabe; Masamitsu Iwasa; Kazumi Kawabe; Hreday N Sapru
Journal:  Clin Exp Hypertens       Date:  2016-01-28       Impact factor: 1.749

Review 9.  Angiotensin II revisited: new roles in inflammation, immunology and aging.

Authors:  Ariela Benigni; Paola Cassis; Giuseppe Remuzzi
Journal:  EMBO Mol Med       Date:  2010-07       Impact factor: 12.137

Review 10.  The renin-angiotensin system modulates inflammatory processes in atherosclerosis: evidence from basic research and clinical studies.

Authors:  Fabrizio Montecucco; Aldo Pende; François Mach
Journal:  Mediators Inflamm       Date:  2009-04-14       Impact factor: 4.711
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