| Literature DB >> 18762968 |
Nelo Eidy Zanchi1, Luiz Roberto Grassmann Bechara, Leonardo Yuji Tanaka, Victor Debbas, Teresa Bartholomeu, Paulo Rizzo Ramires.
Abstract
Myocardial infarction (MI) has been associated with increases in reactive oxygen species (ROS). Exercise training (ET) has been shown to exert positive modulations on vascular function and the purpose of the present study was to investigate the effect of moderate ET on the aortic superoxide production index, NAD(P)H oxidase activity, superoxide dismutase activity and vasomotor response in MI rats. Aerobic ET was performed during 11 weeks. Myocardial infarction significantly diminished maximal exercise capacity, and increased vasoconstrictory response to norepinephrine, which was related to the increased activity of NAD(P)H oxidase and basal superoxide production. On the other hand, ET normalized the superoxide production mostly due to decreased NAD(P)H oxidase activity, although a minor SOD effect may also be present. These adaptations were paralleled by normalization in the vasoconstrictory response to norepinephrine. Thus, diminished ROS production seems to be an important mechanism by which ET mediates its beneficial vascular effects in the MI condition.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18762968 DOI： 10.1007/s00421-008-0861-0
Source DB: PubMed Journal: Eur J Appl Physiol ISSN： 1439-6319 Impact factor: 3.078