BACKGROUND AND AIMS: An increased production of macrophage inflammatory proteins 1 alpha (MIP-1alpha) has been reported to be associated with ulcerative colitis (UC). We investigated whether a polymorphism site in MIP-1alpha was associated with UC in a Chinese population. Additionally, considering the abnormal lipoprotein metabolism in subjects with UC, we also sought to determine whether genetic variation in the apolipoprotein E (ApoE) gene may play a role in the development of UC. MATERIALS AND METHODS: We examined the MIP-1alpha -906 (TA)(4)/(TA)(6) polymorphism and the ApoE polymorphism in a cohort of 162 unrelated UC patients and 220 healthy controls by using restriction fragment length polymorphism assay. RESULTS: A significantly increased frequency of the MIP-1alpha -906 (TA)(6)/(TA)(6) genotype (P = 0.0031, odds ratio [OR] = 1.851, 95% confidence interval [CI] 1.228-2.791), as well as of the ApoE epsilon4+ genotype (P < 0.001, OR = 2.869, 95% CI 1.768-4.657), in patients with UC was proven. Moreover, the carriage of both MIP-1alpha -906 (TA)(6)/(TA)(6) genotype and ApoE epsilon4+ genotype confers greater risk for the development of UC (P < 0.001, OR = 5.432, 95% CI 2.761-10.689). CONCLUSION: These findings suggest that variation in the MIP-1alpha and ApoE genes and their interaction may increase susceptibility to UC. Identifying these novel susceptibility genes, as well as their interactions, will help our understanding of the disease mechanisms of UC and may identify targets for developing novel treatment measures.
BACKGROUND AND AIMS: An increased production of macrophage inflammatory proteins 1 alpha (MIP-1alpha) has been reported to be associated with ulcerative colitis (UC). We investigated whether a polymorphism site in MIP-1alpha was associated with UC in a Chinese population. Additionally, considering the abnormal lipoprotein metabolism in subjects with UC, we also sought to determine whether genetic variation in the apolipoprotein E (ApoE) gene may play a role in the development of UC. MATERIALS AND METHODS: We examined the MIP-1alpha -906 (TA)(4)/(TA)(6) polymorphism and the ApoE polymorphism in a cohort of 162 unrelated UC patients and 220 healthy controls by using restriction fragment length polymorphism assay. RESULTS: A significantly increased frequency of the MIP-1alpha -906 (TA)(6)/(TA)(6) genotype (P = 0.0031, odds ratio [OR] = 1.851, 95% confidence interval [CI] 1.228-2.791), as well as of the ApoE epsilon4+ genotype (P < 0.001, OR = 2.869, 95% CI 1.768-4.657), in patients with UC was proven. Moreover, the carriage of both MIP-1alpha -906 (TA)(6)/(TA)(6) genotype and ApoE epsilon4+ genotype confers greater risk for the development of UC (P < 0.001, OR = 5.432, 95% CI 2.761-10.689). CONCLUSION: These findings suggest that variation in the MIP-1alpha and ApoE genes and their interaction may increase susceptibility to UC. Identifying these novel susceptibility genes, as well as their interactions, will help our understanding of the disease mechanisms of UC and may identify targets for developing novel treatment measures.
Authors: Uli C Broedl; Veronika Schachinger; Arno Lingenhel; Michael Lehrke; Renee Stark; Frank Seibold; Burkhard Göke; Florian Kronenberg; Klaus G Parhofer; Astrid Konrad-Zerna Journal: Inflamm Bowel Dis Date: 2007-04 Impact factor: 5.325
Authors: John R Lynch; Wen Tang; Haichen Wang; Michael P Vitek; Ellen R Bennett; Patrick M Sullivan; David S Warner; Daniel T Laskowitz Journal: J Biol Chem Date: 2003-09-24 Impact factor: 5.157
Authors: G Davatelis; P Tekamp-Olson; S D Wolpe; K Hermsen; C Luedke; C Gallegos; D Coit; J Merryweather; A Cerami Journal: J Exp Med Date: 1988-06-01 Impact factor: 14.307
Authors: Natalia Schneider Nunes; Saejeong Kim; Maggie Sundby; Parwathy Chandran; Scott Robert Burks; Ana Helena Paz; Joseph Alan Frank Journal: World J Gastroenterol Date: 2018-10-14 Impact factor: 5.742