Literature DB >> 18762185

Deep brain stimulation of the nucleus accumbens core and shell: opposite effects on impulsive action.

Thibaut Sesia1, Yasin Temel, Lee Wei Lim, Arjan Blokland, Harry W M Steinbusch, Veerle Visser-Vandewalle.   

Abstract

The nucleus accumbens is gaining interest as a target for deep brain stimulation in refractory neuropsychiatric disorders with impulsivity as core symptom. The nucleus accumbens is composed of two subterritories, core and shell, which have different anatomical connections. Here, we tested the hypothesis that stimulation of the nucleus accumbens core and shell would have different effects on impulsivity. Rats received bilateral stimulation at the level of the nucleus accumbens core or shell during a reaction time task. Stimulation of the nucleus accumbens core significantly decreased impulsivity, while stimulation of the shell increased it. Our results support the hypothesis that the nucleus accumbens is a potential target to treat neuropsychiatric disorders related to impulsivity by deep brain stimulation. However, different behavioral effects resulting from stimulation of the subterritories should be taken into account.

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Mesh：

Year:  2008        PMID： 18762185     DOI： 10.1016/j.expneurol.2008.07.015

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  28 in total

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Journal:  Nat Rev Neurosci       Date:  2015-11-04       Impact factor: 34.870

Review 2.  Neural circuitry and mechanisms of waiting impulsivity: relevance to addiction.

Authors:  Jeffrey W Dalley; Karen D Ersche
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2019-02-18       Impact factor: 6.237

Review 3.  Fractionating impulsivity: neuropsychiatric implications.

Authors:  Jeffrey W Dalley; Trevor W Robbins
Journal:  Nat Rev Neurosci       Date:  2017-02-17       Impact factor: 34.870

4.  Target-specific encoding of response inhibition: increased contribution of AMPA to NMDA receptors at excitatory synapses in the prefrontal cortex.

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5.  Temporally Specific Roles of Ventral Tegmental Area Projections to the Nucleus Accumbens and Prefrontal Cortex in Attention and Impulse Control.

Authors:  Jacques P Flores-Dourojeanni; Coby van Rijt; Marleen H van den Munkhof; Linde Boekhoudt; Mieneke C M Luijendijk; Louk J M J Vanderschuren; Roger A H Adan
Journal:  J Neurosci       Date:  2021-04-09       Impact factor: 6.167

6.  Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens.

Authors:  Xiaoluan Xia; Lingzhong Fan; Chen Cheng; Simon B Eickhoff; Junjie Chen; Haifang Li; Tianzi Jiang
Journal:  Hum Brain Mapp       Date:  2017-05-26       Impact factor: 5.038

7.  Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens.

Authors:  Morgane Besson; David Belin; Ruth McNamara; David Eh Theobald; Aude Castel; Victoria L Beckett; Ben M Crittenden; Amy H Newman; Barry J Everitt; Trevor W Robbins; Jeffrey W Dalley
Journal:  Neuropsychopharmacology       Date:  2010-01       Impact factor: 7.853

8.  Long-term high frequency deep brain stimulation of the nucleus accumbens drives time-dependent changes in functional connectivity in the rodent limbic system.

Authors:  Samuel G Ewing; Anthony A Grace
Journal:  Brain Stimul       Date:  2012-08-23       Impact factor: 8.955

9.  Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans.

Authors:  Tiffany M Love; Christian S Stohler; Jon-Kar Zubieta
Journal:  Arch Gen Psychiatry       Date:  2009-10

10.  Deep brain stimulation of the nucleus accumbens reduces ethanol consumption in rats.

Authors:  Clifford M Knapp; Lisa Tozier; Arlene Pak; Domenic A Ciraulo; Conan Kornetsky
Journal:  Pharmacol Biochem Behav       Date:  2009-01-31       Impact factor: 3.533
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