Literature DB >> 18762149

The many roads to essential genes.

Jun-Rong Wei1, Eric J Rubin.   

Abstract

Antibiotics target functions that are required for bacterial growth and survival. As genetic tools for studying Mycobacterium tuberculosis continue to improve we are increasingly able to identify genes that encode these important effectors. Here we review the strategies that have been used to identify and validate essential genes in mycobacteria and look forward to possible future advances.

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Year:  2008        PMID： 18762149     DOI： 10.1016/S1472-9792(08)70033-7

Source DB:  PubMed          Journal:  Tuberculosis (Edinb)        ISSN： 1472-9792            Impact factor:   3.131


  7 in total

1.  Combining cheminformatics methods and pathway analysis to identify molecules with whole-cell activity against Mycobacterium tuberculosis.

Authors:  Malabika Sarker; Carolyn Talcott; Peter Madrid; Sidharth Chopra; Barry A Bunin; Gyanu Lamichhane; Joel S Freundlich; Sean Ekins
Journal:  Pharm Res       Date:  2012-04-04       Impact factor: 4.200

2.  Dequalinium, a new inhibitor of Mycobacterium tuberculosis mycothiol ligase identified by high-throughput screening.

Authors:  Maria-Teresa Gutierrez-Lugo; Heather Baker; Joseph Shiloach; Helena Boshoff; Carole A Bewley
Journal:  J Biomol Screen       Date:  2009-06-12

3.  Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery.

Authors:  Sean Ekins; Peter B Madrid; Malabika Sarker; Shao-Gang Li; Nisha Mittal; Pradeep Kumar; Xin Wang; Thomas P Stratton; Matthew Zimmerman; Carolyn Talcott; Pauline Bourbon; Mike Travers; Maneesh Yadav; Joel S Freundlich
Journal:  PLoS One       Date:  2015-10-30       Impact factor: 3.240

Review 4.  Handling the Hurdles on the Way to Anti-tuberculosis Drug Development.

Authors:  Pedro F Dalberto; Eduardo V de Souza; Bruno L Abbadi; Christiano E Neves; Raoní S Rambo; Alessandro S Ramos; Fernanda S Macchi; Pablo Machado; Cristiano V Bizarro; Luiz A Basso
Journal:  Front Chem       Date:  2020-11-19       Impact factor: 5.221

5.  Evaluation of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase (DAHPS) as a Vulnerable Target in Mycobacterium tuberculosis.

Authors:  Luiza Galina; Fernanda S M Hopf; Bruno Lopes Abbadi; Nathalia D de Moura Sperotto; Alexia M Czeczot; Mario A Duque-Villegas; Marcia Alberton Perello; Letícia Beatriz Matter; Eduardo Vieira de Souza; Tanya Parish; Pablo Machado; Luiz A Basso; Cristiano V Bizarro
Journal:  Microbiol Spectr       Date:  2022-07-14

6.  Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity.

Authors:  Jim Sun; Vijender Singh; Alice Lau; Richard W Stokes; Andrés Obregón-Henao; Ian M Orme; Dennis Wong; Yossef Av-Gay; Zakaria Hmama
Journal:  PLoS Pathog       Date:  2013-07-18       Impact factor: 6.823

Review 7.  Hit Generation in TB Drug Discovery: From Genome to Granuloma.

Authors:  Tianao Yuan; Nicole S Sampson
Journal:  Chem Rev       Date:  2018-01-31       Impact factor: 60.622
  7 in total

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