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Literature DB >> 18762019

p53 strikes mTORC1 by employing sestrins.

Abstract

The guardian of the genome (p53) elicits cell-cycle checkpoints in response to genotoxic stress. p53 also induces a metabolic checkpoint by inhibiting the mammalian target of rapamycin complex 1 (mTORC1). Recent results by Budanov and Karin, (2008) reveal that p53 exerts its effect on mTORC1 through sestrin1 and sestrin2.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2008 PMID： 18762019 PMCID： PMC5744681 DOI： 10.1016/j.cmet.2008.08.010

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

12 in total

Review 1. Upstream and downstream of mTOR.

Authors: Nissim Hay; Nahum Sonenberg
Journal: Genes Dev Date: 2004-08-15 Impact factor: 11.361

Review 2. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways.

Authors: Arnold J Levine; Zhaohui Feng; Tak W Mak; Han You; Shengkan Jin
Journal: Genes Dev Date: 2006-02-01 Impact factor: 11.361

3. PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes.

Authors: S Velasco-Miguel; L Buckbinder; P Jean; L Gelbert; R Talbott; J Laidlaw; B Seizinger; N Kley
Journal: Oncogene Date: 1999-01-07 Impact factor: 9.867

4. Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.

Authors: Jennifer E Skeen; Prashanth T Bhaskar; Chia-Chen Chen; William S Chen; Xiao-ding Peng; Veronique Nogueira; Annett Hahn-Windgassen; Hiroaki Kiyokawa; Nissim Hay
Journal: Cancer Cell Date: 2006-10 Impact factor: 31.743

5. The antioxidant function of the p53 tumor suppressor.

Authors: Anna A Sablina; Andrei V Budanov; Galina V Ilyinskaya; Larissa S Agapova; Julia E Kravchenko; Peter M Chumakov
Journal: Nat Med Date: 2005-11-13 Impact factor: 53.440

6. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.

Authors: Ken Inoki; Hongjiao Ouyang; Tianqing Zhu; Charlotta Lindvall; Yian Wang; Xiaojie Zhang; Qian Yang; Christina Bennett; Yuko Harada; Kryn Stankunas; Cun-Yu Wang; Xi He; Ormond A MacDougald; Ming You; Bart O Williams; Kun-Liang Guan
Journal: Cell Date: 2006-09-08 Impact factor: 41.582

Review 7. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

Authors: D Grahame Hardie
Journal: Nat Rev Mol Cell Biol Date: 2007-10 Impact factor: 94.444

8. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.

Authors: Andrei V Budanov; Tzipora Shoshani; Alexander Faerman; Elena Zelin; Iris Kamer; Hagar Kalinski; Svetlana Gorodin; Alla Fishman; Ayelet Chajut; Paz Einat; Rami Skaliter; Andrei V Gudkov; Peter M Chumakov; Elena Feinstein
Journal: Oncogene Date: 2002-09-05 Impact factor: 9.867

9. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.

Authors: Andrei V Budanov; Anna A Sablina; Elena Feinstein; Eugene V Koonin; Peter M Chumakov
Journal: Science Date: 2004-04-23 Impact factor: 47.728

10. Delayed ageing through damage protection by the Arf/p53 pathway.

Authors: Ander Matheu; Antonio Maraver; Peter Klatt; Ignacio Flores; Isabel Garcia-Cao; Consuelo Borras; Juana M Flores; Jose Viña; Maria A Blasco; Manuel Serrano
Journal: Nature Date: 2007-07-19 Impact factor: 49.962

24 in total

1. Expression of cell cycle-related genes with cytokine-induced cell cycle progression of primitive hematopoietic stem cells.

Authors: Peter J Quesenberry; Gerri J Dooner; Michael Del Tatto; Gerald A Colvin; Kevin Johnson; Mark S Dooner
Journal: Stem Cells Dev Date: 2010-04 Impact factor: 3.272

2. The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis.

Authors: Batzaya Davaadelger; Ricardo E Perez; Yalu Zhou; Lei Duan; Steven Gitelis; Carl G Maki
Journal: Cancer Biol Ther Date: 2017-07-11 Impact factor: 4.742

Review 3. Crosslink between p53 and metastasis: focus on epithelial-mesenchymal transition, cancer stem cell, angiogenesis, autophagy, and anoikis.

Authors: Ghader Babaei; Azadeh Aliarab; Mehdi Asghari Vostakolaei; Masumeh Hotelchi; Roghaiyeh Neisari; Shiva Gholizadeh-Ghaleh Aziz; Masumeh Rajabi Bazl
Journal: Mol Biol Rep Date: 2021-09-14 Impact factor: 2.316

Review 4. PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects.

Authors: Vera P Krymskaya; Elena A Goncharova
Journal: Cell Cycle Date: 2009-02-06 Impact factor: 4.534

5. The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.

Authors: Elizabeth M Matthew; Lori S Hart; Aristotelis Astrinidis; Arunasalam Navaraj; Nathan G Dolloff; David T Dicker; Elizabeth P Henske; Wafik S El-Deiry
Journal: Cell Cycle Date: 2009-12-15 Impact factor: 4.534

Review 6. Sestrins at the crossroad between stress and aging.

Authors: Jun Hee Lee; Rolf Bodmer; Ethan Bier; Michael Karin
Journal: Aging (Albany NY) Date: 2010-06 Impact factor: 5.682

7. Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity.

Authors: Ruiting Li; Yin Huang; Ian Semple; Myungjin Kim; Zunjian Zhang; Jun Hee Lee
Journal: Am J Physiol Heart Circ Physiol Date: 2019-04-26 Impact factor: 4.733

Review 8. Cell cycle arrest is not senescence.

Authors: Mikhail V Blagosklonny
Journal: Aging (Albany NY) Date: 2011-02 Impact factor: 5.682

9. Hormesis does not make sense except in the light of TOR-driven aging.

Authors: Mikhail V Blagosklonny
Journal: Aging (Albany NY) Date: 2011-11 Impact factor: 5.682

10. The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury.

Authors: Xinqin Kang; Kateryna Petyaykina; Rongya Tao; Xiwen Xiong; X Charlie Dong; Suthat Liangpunsakul
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2014-05-15 Impact factor: 4.052