Literature DB >> 1876183

A 'unified theory' of prion propagation.

C Weissmann1.   

Abstract

There is now very persuasive evidence that the transmissible agent for spongiform encephalopathies such as scrapie, consists of a modified form of the normal host protein PrPc, devoid of any nucleic acid. On the other hand, because there are many different strains of scrapie agent with distinct phenotypes which can be propagated in animals homozygous for the PrPc gene, it has been suggested that a nucleic acid must be a component of the agent. Can the two views be reconciled?

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Year:  1991        PMID： 1876183     DOI： 10.1038/352679a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  66 in total

1.  Scrapie strains maintain biological phenotypes on propagation in a cell line in culture.

Authors:  C R Birkett; R M Hennion; D A Bembridge; M C Clarke; A Chree; M E Bruce; C J Bostock
Journal:  EMBO J       Date:  2001-07-02       Impact factor: 11.598

2.  How now mad cow?

Authors:  P J Harrison; G W Roberts
Journal:  BMJ       Date:  1992-04-11

Review 3.  [The early history of transmissible spongiform encephalopathies exemplified by scrapie].

Authors:  K Schneider; H Fangerau; W H M Raab
Journal:  Nervenarzt       Date:  2007-02       Impact factor: 1.214

4.  Formation of native prions from minimal components in vitro.

Authors:  Nathan R Deleault; Brent T Harris; Judy R Rees; Surachai Supattapone
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-29       Impact factor: 11.205

5.  Selective incorporation of polyanionic molecules into hamster prions.

Authors:  James C Geoghegan; Pablo A Valdes; Nicholas R Orem; Nathan R Deleault; R Anthony Williamson; Brent T Harris; Surachai Supattapone
Journal:  J Biol Chem       Date:  2007-10-16       Impact factor: 5.157

6.  Unraveling prion strains with cell biology and organic chemistry.

Authors:  Adriano Aguzzi
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-02       Impact factor: 11.205

7.  The same primary structure of the prion protein yields two distinct self-propagating states.

Authors:  Natallia Makarava; Ilia V Baskakov
Journal:  J Biol Chem       Date:  2008-04-08       Impact factor: 5.157

8.  In vitro amplification of scrapie and chronic wasting disease PrP(res) using baculovirus-expressed recombinant PrP as substrate.

Authors:  Bonto Faburay; Dongseob Tark; Anumantha G Kanthasamy; Juergen A Richt
Journal:  Prion       Date:  2014       Impact factor: 3.931

9.  Progress and problems in the biology, diagnostics, and therapeutics of prion diseases.

Authors:  Adriano Aguzzi; Mathias Heikenwalder; Gino Miele
Journal:  J Clin Invest       Date:  2004-07       Impact factor: 14.808

Review 10.  Cofactor molecules: Essential partners for infectious prions.

Authors:  Surachai Supattapone
Journal:  Prog Mol Biol Transl Sci       Date:  2020-08-24       Impact factor: 3.622
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