| Literature DB >> 18761566 |
James E Jan1, Russel J Reiter, Michael B Wasdell, Martin Bax.
Abstract
The thalamus has a strong nonphotic influence on sleep, circadian rhythmicity, pineal melatonin production, and secretion. The opening of the sleep gate for nonrapid eye movement sleep is a thalamic function but it is assisted by melatonin which acts by promoting spindle formation. Thus, melatonin has a modulatory influence on sleep onset and maintenance. A remarkable similarity exists between spindle behavior, circadian rhythmicity, and pineal melatonin production throughout life. Together, the thalamic and chronobiological control of sleep leads to a new and improved understanding of the pathophysiology of circadian rhythm sleep disorders and also of the principles of sleep hygiene interventions.Entities:
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Year: 2008 PMID： 18761566 DOI： 10.1111/j.1600-079X.2008.00628.x
Source DB: PubMed Journal: J Pineal Res ISSN： 0742-3098 Impact factor: 13.007