| Literature DB >> 18761421 |
Esther Melgarejo1, Miguel Angel Medina, Francisca Sánchez-Jiménez, José Luis Urdiales.
Abstract
Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for monocytes and macrophages to areas of inflammation. MCP-1 is a prototypical chemokine subject to coordinated regulation by immunomodulatory agents. Since MCP-1 is implicated in multiple inflammatory diseases, it is a potential target for the treatment of these disorders. In this review, we will provide background information and summarize the MCP-1 structure and signaling pathways. Its involvement in multiple diseases, such as tumour development, atherogenesis and rare autoimmune diseases is also revised.Entities:
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Year: 2008 PMID： 18761421 DOI： 10.1016/j.biocel.2008.07.018
Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085