ETHNOPHARMACOLOGICAL RELEVANCE: Mangaba (Hancornia speciosa Gomez) is a medicinal plant frequently cited in ethnopharmacological inventories of the central region of Brazil against gastrointestinal disorders such as diarrhoea, ulcer, gastritis and stomach ache. AIM OF THE STUDY: The hydroalcoholic extract (HE) and infusion (BI) of Hancornia speciosa bark were investigated for their ability to prevent and heal rodent gastric ulcer. MATERIALS AND METHODS: The preventive and healing action of both preparations of Hancornia speciosa were evaluated in experimental models in rodents that simulated this disease in human gastric mucosa. RESULTS: BI did not exert gastroprotective effect, in contrast to HE (500mg/kg, p.o.) that decreased (p<0.05) the severity of gastric damage induced by HCl/ethanol (52%), indomethacin/bethanechol (51%), stress (52%) or pylorus ligature experiments (54%). HE increased (p<0.05) the pH and decreased acid output of gastric juice. This extract promoted increase of mucus amount (3.62mg/wt. tissue vs. 5.81mg/wt. tissue), healing action (67%) and displayed anti-Helicobacter pylori effect. CONCLUSIONS: The antiulcer action of Hancornia speciosa resulted in increase of gastric mucus formation and antioxidant properties of polymeric proanthocyanidins present in the bark composition of this medicinal plant.
ETHNOPHARMACOLOGICAL RELEVANCE: Mangaba (Hancornia speciosa Gomez) is a medicinal plant frequently cited in ethnopharmacological inventories of the central region of Brazil against gastrointestinal disorders such as diarrhoea, ulcer, gastritis and stomach ache. AIM OF THE STUDY: The hydroalcoholic extract (HE) and infusion (BI) of Hancornia speciosa bark were investigated for their ability to prevent and heal rodent gastric ulcer. MATERIALS AND METHODS: The preventive and healing action of both preparations of Hancornia speciosa were evaluated in experimental models in rodents that simulated this disease in humangastric mucosa. RESULTS:BI did not exert gastroprotective effect, in contrast to HE (500mg/kg, p.o.) that decreased (p<0.05) the severity of gastric damage induced by HCl/ethanol (52%), indomethacin/bethanechol (51%), stress (52%) or pylorus ligature experiments (54%). HE increased (p<0.05) the pH and decreased acid output of gastric juice. This extract promoted increase of mucus amount (3.62mg/wt. tissue vs. 5.81mg/wt. tissue), healing action (67%) and displayed anti-Helicobacter pylori effect. CONCLUSIONS: The antiulcer action of Hancornia speciosa resulted in increase of gastric mucus formation and antioxidant properties of polymeric proanthocyanidins present in the bark composition of this medicinal plant.
Authors: Luciane Madureira Almeida; Juliana Ferreira Floriano; Thuanne Pires Ribeiro; Lais Nogueira Magno; Lígia Souza Lima Silveira da Mota; Nei Peixoto; Fátima Mrué; Paulo Melo-Reis; Ruy de Souza Lino Junior; Carlos Frederico de Oliveira Graeff; Pablo José Gonçalves Journal: J Mater Sci Mater Med Date: 2014-06-29 Impact factor: 3.896
Authors: Heyam Mohamed Ali Sidahmed; Najihah Mohd Hashim; Syam Mohan; Siddig Ibrahim Abdelwahab; Manal Mohamed Elhassan Taha; Firouzeh Dehghan; Maizatulakmal Yahayu; Gwendoline Cheng Lian Ee; Mun Fai Loke; Jamuna Vadivelu Journal: Drug Des Devel Ther Date: 2016-01-13 Impact factor: 4.162
Authors: Heyam Mohamed Ali Sidahmed; Ainnul Hamidah Syahadah Azizan; Syam Mohan; Mahmood Ameen Abdulla; Siddig Ibrahim Abdelwahab; Manal Mohamed Elhassan Taha; A Hamid A Hadi; Kamal Aziz Ketuly; Najihah Mohd Hashim; Mun Fai Loke; Jamuna Vadivelu Journal: BMC Complement Altern Med Date: 2013-07-19 Impact factor: 3.659
Authors: Manoela Torres-Rêgo; Allanny Alves Furtado; Mariana Angélica Oliveira Bitencourt; Maira Conceição Jerônimo de Souza Lima; Rafael Caetano Lisbôa Castro de Andrade; Eduardo Pereira de Azevedo; Thaciane da Cunha Soares; José Carlos Tomaz; Norberto Peporine Lopes; Arnóbio Antônio da Silva-Júnior; Silvana Maria Zucolotto; Matheus de Freitas Fernandes-Pedrosa Journal: BMC Complement Altern Med Date: 2016-08-05 Impact factor: 3.659