PURPOSE: To investigate the relationship between retinal vascular caliber and age-related macular degeneration (AMD). DESIGN: Population-based cross-sectional study. METHODS: Three thousand two hundred and eighty (78.7% response rate) Malay Singaporeans aged 40 to 80 years residing in 15 districts of Singapore underwent retinal photography. Retinal vessel caliber was measured from retinal photographs using a validated computer-based technique. AMD was assessed following a modified Wisconsin Age-Related Maculopathy Grading System. RESULTS: Retinal data were available from 3,265 subjects (99.5% of 3,280) for this study. Early and late AMD prevalence were 4.9% (n = 160) and 0.7% (n = 23) of the population, respectively, or in 205 (3.1%) and 30 (0.5%) eyes examined, respectively. After controlling for age and arteriolar caliber, wider venular caliber was associated with higher prevalence of early AMD (odds ratio [OR] per one standard deviation [SD] increment in venular caliber, 1.53; 95% confidence interval [CI], 1.13 to 2.09). This association remained significant after further adjustment for gender, smoking, hypertension, diabetes, and body mass index (OR per one SD, 1.52; 95% CI, 1.11 to 2.09). There was no significant association between retinal arteriolar caliber and early AMD, or between arteriolar or venular caliber and late AMD. CONCLUSIONS: Wider venular caliber was associated independently with early AMD. This finding may suggest that pathogenic processes linking to wider venular caliber be shared by early AMD and common cardiovascular risk factors such as inflammation, dyslipidemia, and endothelial dysfunction.
PURPOSE: To investigate the relationship between retinal vascular caliber and age-related macular degeneration (AMD). DESIGN: Population-based cross-sectional study. METHODS: Three thousand two hundred and eighty (78.7% response rate) Malay Singaporeans aged 40 to 80 years residing in 15 districts of Singapore underwent retinal photography. Retinal vessel caliber was measured from retinal photographs using a validated computer-based technique. AMD was assessed following a modified Wisconsin Age-Related Maculopathy Grading System. RESULTS: Retinal data were available from 3,265 subjects (99.5% of 3,280) for this study. Early and late AMD prevalence were 4.9% (n = 160) and 0.7% (n = 23) of the population, respectively, or in 205 (3.1%) and 30 (0.5%) eyes examined, respectively. After controlling for age and arteriolar caliber, wider venular caliber was associated with higher prevalence of early AMD (odds ratio [OR] per one standard deviation [SD] increment in venular caliber, 1.53; 95% confidence interval [CI], 1.13 to 2.09). This association remained significant after further adjustment for gender, smoking, hypertension, diabetes, and body mass index (OR per one SD, 1.52; 95% CI, 1.11 to 2.09). There was no significant association between retinal arteriolar caliber and early AMD, or between arteriolar or venular caliber and late AMD. CONCLUSIONS: Wider venular caliber was associated independently with early AMD. This finding may suggest that pathogenic processes linking to wider venular caliber be shared by early AMD and common cardiovascular risk factors such as inflammation, dyslipidemia, and endothelial dysfunction.
Authors: Ke Yang; Si Yan Zhan; Yuan Bo Liang; Xinrong Duan; Fenghua Wang; Tien Yin Wong; Lan Ping Sun; Ning-Li Wang Journal: Graefes Arch Clin Exp Ophthalmol Date: 2011-10-05 Impact factor: 3.117
Authors: M Kamran Ikram; Xueling Sim; Sim Xueling; Richard A Jensen; Mary Frances Cotch; Alex W Hewitt; M Arfan Ikram; Jie Jin Wang; Ronald Klein; Barbara E K Klein; Monique M B Breteler; Ning Cheung; Gerald Liew; Paul Mitchell; Andre G Uitterlinden; Fernando Rivadeneira; Albert Hofman; Paulus T V M de Jong; Cornelia M van Duijn; Linda Kao; Ching-Yu Cheng; Albert Vernon Smith; Nicole L Glazer; Thomas Lumley; Barbara McKnight; Bruce M Psaty; Fridbert Jonasson; Gudny Eiriksdottir; Thor Aspelund; Tamara B Harris; Lenore J Launer; Kent D Taylor; Xiaohui Li; Sudha K Iyengar; Quansheng Xi; Theru A Sivakumaran; David A Mackey; Stuart Macgregor; Nicholas G Martin; Terri L Young; Josh C Bis; Kerri L Wiggins; Susan R Heckbert; Christopher J Hammond; Toby Andrew; Samantha Fahy; John Attia; Elizabeth G Holliday; Rodney J Scott; F M Amirul Islam; Jerome I Rotter; Annie K McAuley; Eric Boerwinkle; E Shyong Tai; Vilmundur Gudnason; David S Siscovick; Johannes R Vingerling; Tien Y Wong Journal: PLoS Genet Date: 2010-10-28 Impact factor: 5.917
Authors: Xue Chen; Shi Song Rong; Qihua Xu; Fang Yao Tang; Yuan Liu; Hong Gu; Pancy O S Tam; Li Jia Chen; Mårten E Brelén; Chi Pui Pang; Chen Zhao Journal: PLoS One Date: 2014-09-19 Impact factor: 3.240