BACKGROUND: Isolated reports of neonatal and infant deaths associated with ceftriaxone-calcium precipitation in the lungs and kidneys have prompted a recommendation from the US FDA in June 2007 advising that in patients of all ages, calcium-containing solutions should not be administered simultaneously or within 48 h of the last ceftriaxone dose. OBJECTIVE: To provide a comprehensive review of the literature surrounding the safety of ceftriaxone in the neonatal (< or = 28 days) and geriatric populations (> or = 65 years). METHODS: Multi-database literature search for original research articles, review articles and case reports pertaining to safety of ceftriaxone in the neonatal and geriatric populations. RESULTS/ CONCLUSIONS: Ceftriaxone should be avoided or significantly minimized in neonates (especially those treated concomitantly with intravenous calcium solutions and those with hyperbilirubinemia), and potentially restricted in the geriatric population treated concomitantly with intravenous calcium.
BACKGROUND: Isolated reports of neonatal and infant deaths associated with ceftriaxone-calcium precipitation in the lungs and kidneys have prompted a recommendation from the US FDA in June 2007 advising that in patients of all ages, calcium-containing solutions should not be administered simultaneously or within 48 h of the last ceftriaxone dose. OBJECTIVE: To provide a comprehensive review of the literature surrounding the safety of ceftriaxone in the neonatal (< or = 28 days) and geriatric populations (> or = 65 years). METHODS: Multi-database literature search for original research articles, review articles and case reports pertaining to safety of ceftriaxone in the neonatal and geriatric populations. RESULTS/ CONCLUSIONS:Ceftriaxone should be avoided or significantly minimized in neonates (especially those treated concomitantly with intravenous calcium solutions and those with hyperbilirubinemia), and potentially restricted in the geriatric population treated concomitantly with intravenous calcium.
Authors: Elizabeth M Molyneux; Queen Dube; Francis M Banda; Msandeni Chiume; Isaac Singini; Macpherson Mallewa; Edward C Schwalbe; Robert S Heyderman Journal: Pediatr Infect Dis J Date: 2017-12 Impact factor: 2.129
Authors: Patrick C Donnelly; Rebecca M Sutich; Ryan Easton; Oluwatunmise A Adejumo; Todd A Lee; Latania K Logan Journal: Paediatr Drugs Date: 2017-02 Impact factor: 3.022
Authors: Emily Steadman; Dennis W Raisch; Charles L Bennett; John S Esterly; Tischa Becker; Michael Postelnick; June M McKoy; Steve Trifilio; Paul R Yarnold; Marc H Scheetz Journal: Antimicrob Agents Chemother Date: 2010-01-19 Impact factor: 5.191