Literature DB >> 18759698

Anti-EGFR monoclonal antibodies in metastatic colorectal cancer: time for an individualized approach?

Marwan Fakih1.   

Abstract

Over the past 10 years, healthcare providers involved in the management of metastatic colorectal cancer (MCRC) have seen an explosion in new agents and their combinations. These developments have resulted in an expansion in the options of care for MCRC patients and in a significant improvement in their overall survival. This article reviews the current role of anti-EGFR monoclonal antibodies in the management of MCRC and the identification of recent markers of response that lead towards treatment individualization.

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Year:  2008        PMID: 18759698     DOI: 10.1586/14737140.8.9.1471

Source DB:  PubMed          Journal:  Expert Rev Anticancer Ther        ISSN: 1473-7140            Impact factor:   4.512


  5 in total

1.  Efficacy of the monoclonal antibody EGFR inhibitors for the treatment of metastatic colorectal cancer.

Authors:  M Fakih; R Wong
Journal:  Curr Oncol       Date:  2010-07       Impact factor: 3.677

2.  Nimbolide, a limonoid triterpene, inhibits growth of human colorectal cancer xenografts by suppressing the proinflammatory microenvironment.

Authors:  Subash C Gupta; Sahdeo Prasad; Dhanya R Sethumadhavan; Mangalam S Nair; Yin-Yuan Mo; Bharat B Aggarwal
Journal:  Clin Cancer Res       Date:  2013-06-13       Impact factor: 12.531

Review 3.  Treatment for colorectal liver metastases: a review.

Authors:  Hiroshi Shimada; Kuniya Tanaka; Itaru Endou; Yasushi Ichikawa
Journal:  Langenbecks Arch Surg       Date:  2009-07-07       Impact factor: 3.445

4.  NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway.

Authors:  Arundhati Jana; Nancy L Krett; Grace Guzman; Ahmer Khalid; Ozkan Ozden; Jonas J Staudacher; Jessica Bauer; Seung Hyun Baik; Timothy Carroll; Cemal Yazici; Barbara Jung
Journal:  Oncotarget       Date:  2017-06-06

5.  Colorectal cancer and NF-κB signaling pathway.

Authors:  Parichehr Hassanzadeh
Journal:  Gastroenterol Hepatol Bed Bench       Date:  2011
  5 in total

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