| Literature DB >> 18759434 |
Andrew Martins1, Mark Lautens.
Abstract
A highly effective and operationally simple method for the regioselective deuteration of anilines is presented. A variety of electron-rich and electron-deficient anilines are efficiently deuterated at the ortho and/or para position with respect to the nitrogen in the presence of 1 equiv of conc HCl in D 2O. Under the present conditions, aromatic methoxy groups do not facilitate deuteration, enabling a chemo- and regioselective deuteration of p-anisidine.Entities:
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Year: 2008 PMID： 18759434 DOI： 10.1021/ol801763j
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005