Subchronic toxicity study of urea molasses mineral block in kids.

A study was conducted on twenty indigenous goat kids allocated into two different groups. All animals were offered ad libitum rice straw and berseem hay (40:60). Group I (T(1)) was fed concentrate mixture (100 g/d). Group II (T(2)) was supplemented with urea molasses mineral block (200 g/d). The experiment lasted for 90 days. There was significant decrease in serum sodium (60.68 mEq/L), increase in serum potassium (34.50 mEq/L) and increased activity of AST (340.42 U/L) and ALT (164.96 U/L) was observed in kids of group T(2) in comparison to the controls (T(1)). On histopathological examination mild degenerative changes in kidney of group T(2) with congestion in intertubular vessel, granular cytoplasm of the epithelial cells in PCT and DCT, necrosis and swelling of the epithelial cells, congestion of vessels and cloudy swelling was observed in PCT and DCT. Albuminious mass was also present in tubule. On histopathological observation of liver of kid of group T(2) oedema in liver parenchyma and proliferation of fibrious tissue in periportal area was observed.