Literature DB >> 18758763

Development and validation of a liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of buprenorphine, norbuprenorphine, and metabolites in human urine.

Sherri L Kacinko1, Marta Concheiro-Guisan, Diaa M Shakleya, Marilyn A Huestis.   

Abstract

A liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of buprenorphine (BUP), norbuprenorphine (NBUP), buprenorphine glucuronide (BUP-Gluc), and norbuprenorphine glucuronide (NBUP-Gluc) in human urine was developed and fully validated. Extensive endogenous and exogenous interferences were evaluated and limits of quantification were identified empirically. Analytical ranges were 5-1,000 ng/mL for BUP and BUP-Gluc and 25-1,000 ng/mL for NBUP and NBUP-Gluc. Intra-assay and interassay imprecision were less than 17% and recovery was 93-116%. Analytes were stable at room temperature, at 4 degrees C, and for three freeze-thaw cycles. This accurate and precise assay has sufficient sensitivity and specificity for urine analysis of specimens collected from individuals treated with BUP for opioid dependence.

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Year:  2008        PMID： 18758763      PMCID： PMC2670341          DOI： 10.1007/s00216-008-2326-z

Source DB:  PubMed          Journal:  Anal Bioanal Chem        ISSN： 1618-2642            Impact factor:   4.142


  23 in total

1.  Determination of buprenorphine in human plasma by gas chromatography-positive ion chemical ionization mass spectrometry and liquid chromatography-tandem mass spectrometry.

Authors:  D E Moody; J D Laycock; A C Spanbauer; D J Crouch; R L Foltz; J L Josephs; L Amass; W K Bickel
Journal:  J Anal Toxicol       Date:  1997-10       Impact factor: 3.367

2.  Buprenorphine misuse in Finland.

Authors:  Mauri Aalto; Jukka Halme; Jukka-Pekka Visapää; Mikko Salaspuro
Journal:  Subst Use Misuse       Date:  2007       Impact factor: 2.164

3.  Gas chromatographic-mass spectrometric quantitation of urinary buprenorphine and norbuprenorphine after derivatization by direct extractive alkylation.

Authors:  A M Lisi; R Kazlauskas; G J Trout
Journal:  J Chromatogr B Biomed Sci Appl       Date:  1997-04-25

4.  Enzyme immunoassay validation for the detection of buprenorphine in urine.

Authors:  V Cirimele; P Kintz; S Lohner; B Ludes
Journal:  J Anal Toxicol       Date:  2003-03       Impact factor: 3.367

5.  Radioimmunoassay of buprenorphine in urine: studies in patients and in a drug clinic.

Authors:  C W Hand; K E Ryan; S K Dutt; R A Moore; J O'Connor; D Talbot; H J McQuay
Journal:  J Anal Toxicol       Date:  1989 Mar-Apr       Impact factor: 3.367

6.  Safety and side-effects of buprenorphine in the clinical management of heroin addiction.

Authors:  W R Lange; P J Fudala; E M Dax; R E Johnson
Journal:  Drug Alcohol Depend       Date:  1990-08       Impact factor: 4.492

7.  Analysis of buprenorphine and its N-dealkylated metabolite in plasma and urine by selected-ion monitoring.

Authors:  Y Blom; U Bondesson; E Anggård
Journal:  J Chromatogr       Date:  1985-02-27

8.  Rapid quantification of buprenorphine-glucuronide and norbuprenorphine-glucuronide in human urine by LC-MS-MS.

Authors:  S Hegstad; H Z Khiabani; E L Øiestad; T Berg; A S Christophersen
Journal:  J Anal Toxicol       Date:  2007-05       Impact factor: 3.367

9.  Online solid-phase extraction liquid chromatography-electrospray-tandem mass spectrometry analysis of buprenorphine and three metabolites in human urine.

Authors:  An-Chan Liu; Tzuen-Yeuan Lin; Lien-Wen Su; Ming-Ren Fuh
Journal:  Talanta       Date:  2007-11-09       Impact factor: 6.057

10.  Development of a fluoroimmunoassay for the detection of buprenorphine in urine.

Authors:  L Debrabandere; M Van Boven; P Daenens
Journal:  J Forensic Sci       Date:  1995-03       Impact factor: 1.832
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  5 in total

1.  Confirmatory analysis of buprenorphine, norbuprenorphine, and glucuronide metabolites in plasma by LCMSMS. Application to umbilical cord plasma from buprenorphine-maintained pregnant women.

Authors:  Marta Concheiro; Hendreé Jones; Rolley E Johnson; Diaa M Shakleya; Marilyn A Huestis
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2010-01-01       Impact factor: 3.205

2.  Simultaneous quantification of buprenorphine, norbuprenorphine, buprenorphine-glucuronide and norbuprenorphine-glucuronide in human umbilical cord by liquid chromatography tandem mass spectrometry.

Authors:  Marta Concheiro; Diaa M Shakleya; Marilyn A Huestis
Journal:  Forensic Sci Int       Date:  2009-04-29       Impact factor: 2.395

3.  Urinary excretion of buprenorphine, norbuprenorphine, buprenorphine-glucuronide, and norbuprenorphine-glucuronide in pregnant women receiving buprenorphine maintenance treatment.

Authors:  Sherri L Kacinko; Hendree E Jones; Rolley E Johnson; Robin E Choo; Marta Concheiro-Guisan; Marilyn A Huestis
Journal:  Clin Chem       Date:  2009-03-26       Impact factor: 8.327

4.  Simultaneous quantification of buprenorphine, norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide in human placenta by liquid chromatography mass spectrometry.

Authors:  Marta Concheiro-Guisan; Diaa M Shakleya; Marilyn A Huestis
Journal:  Anal Bioanal Chem       Date:  2009-02-27       Impact factor: 4.142

5.  A sensitive, simple and rapid HPLC-MS/MS method for simultaneous quantification of buprenorpine and its N-dealkylated metabolite norbuprenorphine in human plasma.

Authors:  Yi-Ya Wang; Xiao-Hang Shen; Hao Li; Feng-Ju Chen; Yan Fu; Li Ding
Journal:  J Pharm Anal       Date:  2013-01-04
  5 in total

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